海星甾醇抗实验性心律失常作用  

Anti-arrhythmic effect of starfish sterol

作　　者：许东晖[1] 朱良[1] 梅雪婷[1] 陈丽琼[1] 孟学强[1] 王胜[1] 许实波[1] 

机构地区：[1]中山大学药学院中药与海洋药物实验室,广东广州510275

出　　处：《药学学报》2004年第7期504-508,共5页Acta Pharmaceutica Sinica

基　　金：国家 8 63计划资助项目 ( 2 0 0 1AA62 0 40 8;2 0 0 3AA62 0 40 8);广东省重大科技兴海项目

摘　　要：目的　研究海星甾醇 [丁二酸 (5 雄甾烯 17 酮 3β 羟基 )二酯 ]对实验性心律失常的作用。 方法　通过iv乌头碱、哇巴因、BaCl2 、肾上腺素、冠脉结扎和电刺激复制各种动物心律失常模型 ,在预先po海星甾醇 ,观察其对实验性心律失常的预防作用。结果　海星甾醇可分别增加乌头碱、哇巴因、BaCl2 诱发心律失常所需剂量 ,延迟VP ,VT ,VF和CA的出现 ;可延迟肾上腺素所致兔VT的出现 ,缩短恢复正常心律的时间 ;可减少冠脉结扎再灌注所致室性心律失常 ;可提高电刺激兔所致室颤阈值。Aim To study the effect of modified starfish sterol [C03, succinic acid (5-epiandroene-17-one-3β-ol) diester] on experimental arrhythmias. Methods Arrhythmias were induced by drugs (Aco, Oua, BaCl 2 and adrenalin) iv, ligating the left anterior descending coronary artery and electricity. Results C03 71.4 mg·kg -1 (ig) was shown to increase the dose of Oua inducing VP, VT, VF and CA in guinea pigs (P<0.01); C03 (26.8, 80.4 mg·kg -1) was found to increase the dose of Aco inducing VF and CA in rats (P<0.01); C03 (8.9, 26.8, 80.4 mg·kg -1) increase the dose of barium chloride and delay the onset time of ventricular arrhythmias (P<0.01); C03 (14.1, 42.3 mg·kg -1) shorten time of recovering induced by adrenalin in rabbits (P<0.01); C03 (80.4 mg·kg -1) was shown to reduce the number of ventricular arrhythmias induced by coronary artery ligation in rats (P<0.05), C03 increase VFT induced by electricity in rabbits, VFT of C03 14.1 mg·kg -1 increased from (5.1±2.5) V to (11.0±2.7) V (P<0.01), 42.3 mg·kg -1 increased from (6.1±1.7) V to (15±5) V (P<0.01). Conclusion Starfish sterol has anti-arrhythmic effect.

关 键 词：海星甾醇 抗心律失常 海洋药物 

分 类 号：R972.2[医药卫生—药品]