睾丸素母液中两个新差向异构体的分离与结构鉴定  

The isolation and identification of two new epimer from the mother liquid of testosterone

作　　者：杨中铎[1] 王友富 林力波 李援朝[1] 

机构地区：[1]中国科学院上海生命科学院药物研究所,上海201203 [2]浙江仙居制药二分厂

出　　处：《药学学报》2004年第7期528-530,共3页Acta Pharmaceutica Sinica

摘　　要：目的　研究药物睾丸素中所含的杂质。方法　应用柱色谱方法进行分离和纯化 ,NMR和MS等波谱解析化学结构。结果　从睾丸素母液中分离得到 2个化合物。结论　化合物 1,2为新差向异构体 ,其结构分别鉴定为 :3α 乙氧基雄甾 4 烯 17β 醇 (1) ,3β 乙氧基雄甾 4 烯 17β 醇 (2 )Aim To study the impurity of the drug testosterone. Methods Chromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis. Results Two new epimers were isolated from the mother liquid of the drug. Conclusion These new epimers were identified as 3α-ethoxyandrost-4-en-17β-ol, 3β-ethoxyandrost-4-en-17β-ol.

关 键 词：睾丸素 3α-乙氧基雄甾-4-烯-17β-醇 3β-乙氧基雄甾-4-烯-17β-醇 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]