氯苄律定的结构表征(英文)  

Structural characterization of chlorobenzylidine

作　　者：李忠红[1] 倪坤仪[1] 周帼雄[2] 张灿[1] 黄文龙[1] 彭司勋[1] 

机构地区：[1]中国药科大学,江苏南京210009 [2]江苏省药品检验所,江苏南京210008

出　　处：《药学学报》2004年第7期546-550,共5页Acta Pharmaceutica Sinica

基　　金：NationalNewDrugResearchFund ( 870 41)andNaturalScienceFundofJiangsuProvince (BK9910 1)

摘　　要：目的　研究氯苄律定的结构与晶型。方法　采用卡氏水分滴定法 ,傅立叶变换红外光谱法 ,热分析 ,单晶和粉末X射线衍射法对氯苄律定的结构及晶型进行了研究。结果　氯苄律定及其非对映异构体可用不同的熔点来区分。氯苄律定晶型A为三斜晶系 ,空间群为P-1 ,每个晶胞中有两个互为镜象的分子 ,为一水合物。并对氯苄律定的两种晶型进行了鉴定。Aim To study the structure and crystal forms of chlorobenzylidine. Methods Karl Fischer titrimetry, FTIR, thermal analysis, single and powder X-ray diffraction were used for the studies of the structure of chlorobenzylidine and for the identification of two forms of chlorobenzylidine. Results Chlorobenzylidine and its diastereoisomer have been studied in this article. They can be distinguished by their different melting points. Two crystal forms of chlorobenzylidine (form A and form B) have also been detected and studied. Form A was studied by single-crystal X-ray diffraction, it crystallized in the triclinic system, space group P - 1, with two formula units per cell, is monohydrate. Karl Fischer titrimetry, FTIR, thermal analysis and powder X-ray diffraction were used for identification of the two forms.Conclusion The studies of structure and crystal forms of chlorobenzylidine are very useful for the clinical research and the selection of recrystallization process.

关 键 词：氯苄律定 晶型 热分析 X射线衍射 

分 类 号：R917[医药卫生—药物分析学]