海藻酸钠骨架材料中药物释放的影响因素  

Studies on the influencing factors on the drug release from sodium alginate matrices

作　　者：聂淑芳[1] 吴学明[1] 刘宏飞[1] 姜华威[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《药学学报》2004年第7期561-565,共5页Acta Pharmaceutica Sinica

摘　　要：目的　以海藻酸钠为亲水骨架材料 ,考察药物从海藻酸钠骨架片中释放的体外影响因素。方法　以茶碱为模型药物 ,采用直接压片法制备了茶碱海藻酸钠亲水骨架片 ,通过对骨架片膨胀性、吸水性以及溶蚀性的考察 ,研究了影响药物从海藻酸钠骨架材料中释放的体外因素。结果　茶碱海藻酸钠骨架片的释药速率和释药机理与骨架片中海藻酸钠粘度、释放介质pH值、离子强度以及转速均有关。结论　海藻酸钠能有效地控制骨架片中药物的释放 。Aim To investigate the in vitro influencing factors on drug release from matrices with sodium alginate as the hydrophilic polymer. Methods Sodium alginate hydrophilic matrix tablets were prepared by direct compression method with theopylline as a model drug. The in vitro influencing factors on drug release behavior from matrices were studied by investigating the swelling, water uptake and erosion characteristics of pure sodium alginate matrices. Results The results showed that drug release rate and drug release mechanism were both related to the viscosity of sodium alginate used in matrices, pH values and ionic strength of dissolution media and rotation speeds. Conclusion Sodium alginate can be tailor-made to suit the demands of applicants in sustained delivery systems as a good candidate of hydrophilic polymer.

关 键 词：海藻酸钠 茶碱 骨架片 体外释放 

分 类 号：R943[医药卫生—药剂学] R944.4[医药卫生—药学]