Effects of Electroacupuncture on Learning,Memory and Formation System of Free Radicals in Brain Tissues of Vascular Dementia Model Rats  

作　　者：王黎 唐纯志 赖新生 毛树章 

机构地区：[1]Acupuncture & Massage College of Guangzhou University of TCM,510405 Guangdong Province

出　　处：《Journal of Traditional Chinese Medicine》2004年第2期140-143,共4页中医杂志（英文版）

摘　　要：In order to observe the regulative effect of electro-acupuncture on the formation system of free radicals in the brain tissues and learning and memory in vascular dementia (VD) model rats, the Morris's water labyrinth was used for testing the learning ability and memory in VD model rats made by 4-vessel occlusion method, and the activities or contents of nitric oxide (NO), NO synthase (NOS), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) were determined. Results showed that the mean escape latency in the electro-acupuncture group was markedly reduced in place test, and the times swam the place of the plate-form in the original plate-form quadrant were significantly more than those in the rest three quadrants in spatia1 probe test as compared with the model group. In the electro-acupuncture group and the nimodipine group the contents of NO and MDA and the activity of NOS were decreased, while the activities of SOD and GSH-Px were increased. It is indicated that electro-acupuncture can modulate the production and clearance of free radicals, and improve the ability of learning and memory of the VD model rats.In order to observe the regulative effect of electro-acupuncture on the formation system of free radicals in the brain tissues and learning and memory in vascular dementia(VD)model rats,the Morris's water labyrinth was used for testing the learning ability and memory in VD model rats made by 4-vessel occlusion method,and the activities or contents of nitric oxide(NO),NO synthase(NOS),superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px)were determined.Results showed that the mean escape latency in the electro-acupuncture group was markedly reduced in place test, and the times swam the place of the plate-form in the original plate-form quadrant were significantly more than those in the rest three quadrants in spatial probe test as compared with the model group.In the electro-acupuncture group and the nimodipine group the contents of NO and MDA and the activity of NOS were decreased,while the activities of SOD and GSH-Px were increased.It is indicated that electro-acupuncture can modulate the production and clearance of free radicals,and improve the ability of learning and memory of the VD model rats.

关 键 词：电针治疗 学习能力 记忆力 自由因子 大脑组织 脉管性痴呆 老鼠模型 VD 

分 类 号：R245[医药卫生—针灸推拿学]