缺血性疾病与治疗性血管再生  

Ischemic disease and therapeutic angiogenesis

作　　者：王冬[1] 叶星沈[1] 

机构地区：[1]中国医学科学院中国协和医科大学基础医学研究所解剖与组织胚胎学系,北京100005

出　　处：《基础医学与临床》2004年第3期245-251,共7页Basic and Clinical Medicine

基　　金：国家自然科学基金 (30 170 4 83)

摘　　要：冠心病、外周动脉阻塞性疾病等缺血性疾病严重威胁着人类的健康 ,尤其是以终末小血管弥漫性受损为主的病变目前临床治疗无法取得满意疗效 ,根据血管生成的机制应用促血管生成因子、转基因治疗及细胞治疗等多种方式进行的治疗性血管再生为此类疾病的治愈带来了希望。The ischemic diseases, such as Coronary heart disease(CHD) and peripheral arterial occlusive disease(PAOD), has increasely do severe harm to peoples'health. In particular, at present the alternative clinic treatment failed to achieve satisfying effect on the therapy for diffuse or distal artery-derived ischemic disease. Given that facts, therapeutic angiogenesis, which is based on the mechanism of angiogenesis and take advantages of application of angiogenic factors, transgenic therapy and cellular therapy, is a clinical-therapeutic potential for those ischemic disease.

关 键 词：缺血性疾病 治疗性血管再生 促血管生成因子 基因治疗 细胞治疗 

分 类 号：R543[医药卫生—心血管疾病]