注意力缺陷及注意缺陷多动障碍患儿局部脑血流灌注的研究  

Research on regional cerebral blood flow in children with attention deficit or/and hyperactivity-impulsivity disorder

作　　者：刘军[1] 苏林雁[1] 杜亚松[2] 吴永刚[3] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,湖南长沙410011 [2]上海市精神卫生中心,上海200030 [3]中南大学湘雅二医院同位素科,湖南长沙410011

出　　处：《中国儿童保健杂志》2004年第1期17-19,共3页Chinese Journal of Child Health Care

基　　金：国家自然科学基金项目 (39770 2 77)

摘　　要：【目的】　探讨注意缺陷 /多动障碍 (ADHD)各亚型局部脑血流 (rCBF)特点以及与不同临床类型的关系。　【方法】　用单光子发射计算机断层扫描 (SPECT)测定了 40例ADHD患儿和 11例正常儿童rCBF灌注情况。【结果】　定性分析结果显示 ,ADHD患儿低rCBF灌注量的发生率 ( 5 7.5 %)高于正常儿童 ( 9%) ,低灌注部位涉及额叶、颞叶、枕叶和丘脑 ,以额叶发生率最高 ;伴有多动 冲动组低rCBF灌注量的发生率 ( 66.7%)高于注意缺陷组 (4 7.3 %) ,同时 ,伴有多动 冲动组中在所有rCBF降低的脑区中 ,左侧占 14例次 ,右侧占 10例次 ,左右侧rCBF差异有显著性。　【结论】　额叶rCBF降低与ADHD行为抑制缺陷相关 。To understand the characteristic of regional cerebral blood flow (rCBF)of inattentive type and combined subtype of ADHD. rCBF was examined with single photon emission computed tomograghy in 40 children with ADHD and 11 healthy normal boys as controls. Qualitative analysis results showed that the rate of low rCBF was significantly higher in ADHD groups (57.5%)than that in controls(9%).The low rCBF brain zones included frontal lobe, temporal lobe, occipital lobe and thalamus, among which the highest rate was observed in frontal lobe. The rate of low rCBF was significantly higher in the combined subtype groups (66.7%)than that in the inattentive type groups(47.3%).At the same time, the low rCBF in the left brain zones of the combined subtype group was 14 cases,while in the right zones was 10 cases, showing significant difference between the brain zones of the two sides. [Conclusion] The results of the study suggest that the lower rCBF in frontal lobe links up with behavior disinhibition, meanwhile there is relation between the lower rCBF in left brain zones and the intensity of the state of ADHD.

关 键 词：注意缺陷/多动障碍 单光子发射计算机断层扫描 局部脑血流灌注 

分 类 号：R174.6[医药卫生—妇幼卫生保健]