小儿晚发型维生素K缺乏性出血3970例分析  

Analysis of 3 970 cases of late vitamin K deficiency bleeding in infancy

作　　者：张会丰[1] 王卫平[2] 

机构地区：[1]河北医科大学第二医院儿科,河北石家庄050000 [2]复旦大学儿科医院,上海200032

出　　处：《中国儿童保健杂志》2004年第1期31-32,共2页Chinese Journal of Child Health Care

基　　金：河北省科研基金资助项目 (982 7630 3D) ;河北计划生育委员会科研基金资助项目 (980 3 ;990 7;2 0 0 1 - 1 2 )

摘　　要：【目的】　全面了解我国晚发型维生素K缺乏性出血的状况和发病特点。　【方法】　通过计算机光盘检索系统 ,结合中文科技资料目录、中国医学文摘等检索工具 ,以维生素K为主题词 ,检索 1979～ 2 0 0 0年全部含有维生素K的文献。从中挑选出涉及晚发型维生素K缺乏性出血的临床病例报告文献。　【结果】　得到 165篇原始文献 ,报告符合晚发型维生素K缺乏性出血的病例 3 970例 ,男童 2 874例 ,女童 10 96例 ,男女之比为 2 .62∶1;母乳喂养3 5 5 5例 ( 89%) ,混合喂养 3 0 0例 ( 8%) ,人工喂养 115例 ( 3 %)。发病年龄低于 4周 3 16例 ( 8%) ,高于 8周 5 0 6例( 13 %) ,4～ 8周 3 14 8例 ( 79%)。 3 970例中 3 674例发生颅内出血 ,发生率为 92 %;死亡 891例 ,死亡率 2 2 %。　【结论】　我国晚发型维生素K缺乏性出血发病形势严峻。母乳喂养是发病的高危因素 ;发病的峰年龄 4～ 8周 ;To understand the status and characteristic of late vitamin K deficiency bleeding in China. By mean of the Chinese computer retrieve system and vitamin K as subject heading,look for the total documents of late vitamin K deficiency bleeding from 1979 till 2000. The total of 3 970 cases of late vitamin K deficiency were obtained from 165 pieces of eligible documents.The boys were 2 874 cases, the girls were 1 096 cases. The rate of boys to girls 2.62∶1. The exclusive breast fed infants were 3 555(89%); predominant breast fed infants were 300(8%),and the formula fed were 115(3%). The peak age was 4～8 weeks (3 148,79%),316(8%) cases were inferior to 4 weeks and 506(13%) cases went beyond 8 weeks. The majority(92%), 3 674 out of 3 970 cases, occurred to intracranial haemorrhage. The numbers of death were 891(22%). [Conclusions] Breast feeding is a risk factor for late vitamin K deficiency bleeding. The peak age is 4～8 weeks. The rate of occurring intracranial haemorrhage is high.

关 键 词：晚发型维生素K缺乏性出血 母乳喂养 婴儿 

分 类 号：R722[医药卫生—儿科]