我国部分地区学龄儿童抗DNA酶B正常值水平探讨  

Normal value of anti-DNase B titers for school children in China

作　　者：陈剑光[1] 董太明[1] 黄震东[1] 陈志红[1] 吴红穗[1] 苏健[1] 卓绮玲[1] 

机构地区：[1]广东省人民医院医学研究中心,广州510080

出　　处：《中华风湿病学杂志》2004年第7期417-419,共3页Chinese Journal of Rheumatology

摘　　要：目的探讨我国部分地区学龄儿童抗DNA酶B抗体正常值水平.方法从1994年9月至1995年8月,对我国不同地理位置4个省的学龄儿童[年龄8～13岁,平均(11.0±2.3)岁],包括湖北103名、广东589名、四川283名、吉林215名,共1190名(男618名,女572名),每3个月抽血1次,用微量法统一测定血清抗DNA酶B抗体水平.结果①抗DNA酶B的几何均值(GMT)水平:各地区间均差异有显著性(P＜0.01),以湖北最高(198 U/ml),其次是广东(140 U/ml)、四川(122 U/ml),吉林最低(85 U/ml).GMT水平较高的季节多在冬、春和秋季,夏季普遍较低.男女间差异无显著性(P＞0.05).②抗DNA酶B正常值上限:我国不同地区学龄儿童正常值上限为200～320 U/ml,4省合计为240 U/ml.其中湖北最高(320 U/ml),广东次之(240 U/ml),吉林和四川相同(200U/ml).结论正常值上限(240 U/ml)基本反映了我国不同地区学龄儿童抗DNA酶B正常水平,结果可信,可作正常值供临床和科研工作者参考.Objective To determine the normal value of serum anti-DNase B titers in school children of China. Methods From September 1993 to August 1994, 1190 school children aged 8~13 years from Hubei, Guangdong, Sichuan, and Jilin provinces of China were included in our study. Serum anti-DNase B titers were determined with microtiter method every three months for each healthy participant during the study. Results ① The geometric mean titers (GMT) of anti-DNase B: there were significant differences (P<0.01) in GMT in different provinces, with the highest in Hubei (198 U/ml) and the lowest in Jinlin (85 U/ml). The GMT were higher during fall, winter, and spring seasons, lower in summer. ② The upper limit of normal (ULN) of anti-DNase B was as follows: 320 U/ml in Hubei, 240 U/ml in Guangdong, 200 U/ml in Jilin and Sichuan. The ULN in all 4 provinces was 240 U/ml. Conclusion 240 U/ml can be used as the normal value of anti-DNase B titer in schoolchildren of China for reference in clinical and experimental study.

关 键 词：学龄儿童 抗DNA酶B 抗脱氧核糖核酸酶B 湖北 广东 四川 吉林 抗体 测定 

分 类 号：R725.9[医药卫生—儿科]