抗甲状腺药物诱导的狼疮样综合征循证诊断与治疗的个案分析  

Evidence-Based Diagnosis and Treatment of Lupus Erythematosus-Like Syndrome Induced by Anti-Thyroid Drugs

作　　者：杨立川[1] 肖艰[1] 李孜[1] 苏白海[1] 冀玲[1] 刘先蓉[1] 樊均明[1] 

机构地区：[1]四川大学华西医院肾脏内科,成都610041

出　　处：《中国循证医学杂志》2004年第7期499-502,共4页Chinese Journal of Evidence-based Medicine

摘　　要：狼疮样综合征和抗中性粒细胞胞浆抗体 (ANCA)阳性的血管炎合并甲亢在临床中十分罕见。为了找出这三种疾病之间的关系 ,作者借助循证医学的方法 ,根据患者病情 ,提出临床问题 ,从PubMed(196 6～ 2 0 0 3年 )、中国生物医学文献数据库 (CBM ) (1978～ 2 0 0 3年 )、荷兰医学文摘数据库 (EMBase) (1974～ 2 0 0 3年 )查找相关信息。结果发现抗甲状腺药物的副反应是对该病例的最好解释 ,并据此采取了相应治疗措施 ,使患者病情获得明显好转。To di agnose and treat a patient with rare lupus erythematosus-like syndrome and anti neutrophil cytoplasmic antibodies (ANCA) positive vasculitis with graves' disea se by applying the approach of evidence-based medicine. Clinical problems were raised based on the patient condition and PubMed (1966-2003), CBM (1978-200 3),EMBASE(1974-2003) were searched for the related information. We found th at the best explaination for this case was antithyroid drugs' side effect, and the patient was obvious better after treatment. JP

关 键 词：循证医学 抗甲状腺药物副作用 狼疮样综合征 抗中性粒细胞胞浆抗体 

分 类 号：R595.3[医药卫生—内科学]