复方丹参方对肾上腺素血瘀模型大鼠血小板粘聚性及TXB_2、6-Keto-PGF_(1α)的影响  

Effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB_2、6-Keto-PGF_(1α) in Blood Stasis Syndromes Model Rats

作　　者：刘婷[1] 秦彩玲[1] 张毅[1] 杨佳[1] 孙有富[1] 张淑运[1] 张伯礼[2] 

机构地区：[1]中国中医研究院中药研究所,北京100700 [2]天津中医药大学,天津300193

出　　处：《中国实验方剂学杂志》2004年第4期35-38,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展规划项目 (1 9990 5440 3)

摘　　要：目的 :研究复方丹参方对肾上腺素血瘀模型大鼠血小板粘聚性及TXB2 、6 Keto PGF1α含量的影响。方法 :采用皮下注射肾上腺素加冰水冷浴法造大鼠血瘀模型 ,观察复方丹参方对血小板粘聚性及TXB2 、6 Keto PGF1α 含量的影响。结果 :大鼠肾上腺素血瘀模型组与正常对照组比较 ,血浆血小板聚集性、粘附性均显著升高 ;复方丹参方对肾上腺素血瘀模型大鼠血小板粘聚性升高有明显抑制作用 ,对血浆中TXB2 及血浆中 6 Keto PGF1α、腹主动脉组织 6 Keto PGF1α均有明显升高的作用 ,对TXB2 6 Keto PGF1α无明显影响。结论 :此血瘀模型复制成功 ,推测其升高血小板粘聚性的机理与TXB2 PGI2 系统无明显关系。Ojbect:To study the effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB 2、6 Keto PGF 1α in Blood Stasis Syndromes Model Rats.Methods:The rat blood stasis syndromes model was caused by subcutaneous injection of Adr and ice\|bathing.We studied the effects of Fufangdanshenfang on platelet aggregation,adhesion,TXB 2 and 6 Keto PGF 1α in blood stasis syndromes model rats.Results:The results indicated that compared with normal rats,the platelet aggregation and platelet adhesion were markedly increased.Fufangdancanfang was antagonized the increase of platelet adhesion and ADP\|induced platelet aggregation in model rats.Fufangdancanfang markedly increased the level of TXB 2\,6 Keto PGF 1α in plasma and the content of abdominal aorta tissue 6 Keto PGF 1α in model rats,but had little effect on the proportion of TXB 2/6 Keto PGF 1α .Conclusion:The results suggested that rat blood stasis syndromes model of Adr was caused successfully,and we inferred that the effects on the platelet aggregation and platelet adhesion might not be connected with the system TXB 2\|PGI 2.Fufangdancanfang was antagonized the increase of platelet adhesion and ADP\|induced platelet aggregation in model rats.

关 键 词：复方丹参方 肾上腺素 血小板聚集性 血小板粘附性 TXB2 

分 类 号：R285.5[医药卫生—中药学]