代谢综合征患者瘦素抵抗的研究  

Studies on Lepfin resistance of metabolic syndrome

作　　者：王维敏[1] 马向华[2] 

机构地区：[1]南京大学医学院附属鼓楼医院内分泌科,江苏南京210008 [2]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《医学研究生学报》2004年第7期610-612,共3页Journal of Medical Postgraduates

摘　　要：目的 :研究代谢综合征 (MS)患者瘦素抵抗的状况。　方法 :选取 5 0例MS患者 (MS组 )和 30例正常人 (正常对照组 ) ,分别测定体重指数 (BMI)、腰臀比 (WHR)、收缩压 (SBP)、舒张压 (DBP)、血清瘦素水平 (leptin)、空腹血糖(FPG)、空腹胰岛素 (FIns)、血清总胆固醇 (TC)、三酰甘油 (TG)、低密度脂蛋白胆固醇 (LDL C)、高密度脂蛋白胆固醇(HDL C)以及脂蛋白 (a)〔LP(a)〕 ,并计算HOMA胰岛素抵抗指数 (HOMA IR)。　结果 :与正常对照组相比 ,MS组血清瘦素水平显著上升 [(2 3.82± 1 5 .6 3) μg/Lvs(1 1 .2 0± 4 .70 ) μg/L ,P <0 .0 1 ],BMI、WHR、SBP、DBP、HOMA IR、TC、TG、LDL C、HDL C亦明显升高 ,而两组间LP(a)差异无显著性意义 (P >0 .0 5 )。　结论 :MS患者血清瘦素水平显著升高 ,可能由于该患者群存在一定程度的瘦素抵抗 ,使正常的脂肪 胰岛素轴反馈机制受到破坏、瘦素抑制胰岛素分泌的能力下降 。Objective: To investigate Leptin resistance of patients with metabolic syndrome. Methods: 50 patients with metabolic syndrome and 30 health persons as control were investigated. Body mass index(BMI)、waist to hip ratio(WHR)、blood pressure(Bp) were recorded. Serum Leptin、plasma glucose、insulin、total cholesterol(TC)、triglyceride(TG)、high density lipoprotein cholesterol(HDL C)、low density lipoprotein cholesterol(LDL C)、lipoprotein(a) were determined,and HOMA IR was calculated. Results: Compared to controls, serum Leptin concentration was significantly higher in metabolic syndrome〔(23.82±15.63)μg/L vs (11.20±4.70)μg/L, P <0.01〕. Conclusion: The patients with metabolic syndrome had significantly higher values of Leptin than that of controls, the defective leptin suppression of insulin secretion could contribute to metabolic syndrome.

关 键 词：瘦素 代谢综合征 瘦素抵抗 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌]