生脉注射液加护心通用于心肺脑复苏的临床研究  

Clinical study of Shengmai injection(生脉注射液) and creatine phosphate on cardiac pulmonary cerebral resuscitation

作　　者：许荣廷[1] 宋慧玲[1] 倪一虹[1] 隋文娟[1] 胡俊霞[1] 何旭东[1] 

机构地区：[1]山东大学第二医院,山东济南250033

出　　处：《中国中西医结合急救杂志》2004年第4期221-223,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：山东省中医药科技发展重点项目资助(2002226)

摘　　要：目的 :观察中西医结合方法用于心肺复苏后延续生命支持阶段对维护心脏和循环功能、提高心肺脑复苏成功率的效果。方法 :6 9例心搏骤停经心肺复苏心搏恢复患者 ,随机分为中西医结合组 35例和对照组34例 ,两组均按“2 0 0 0年国际心肺复苏与心血管急救指南”进行积极心肺复苏 ,常规使用抢救措施和急救药物 ;中西医结合组在上述救治基础上 ,在心搏恢复后即刻或延续生命支持阶段早期联合应用生脉注射液和护心通静脉滴注 ,每日 1次 ,连用 3～ 7d。结果 :1两组≤ 5 min开始心肺复苏者心肺脑复苏成功率最高 ,6～ 10 min次之 ;中西医结合组各时间段复苏成功率均高于对照组 ;11～ 15 min对照组无复苏成功者。 2各种原因所致的心搏骤停中 ,中西医结合组心肺脑复苏成功率为 6 3% (2 2 / 35例 ) ,明显高于对照组 32 % (11/ 34例 ) ,P <0 .0 1。3心律、平均动脉压、最大氧耗指数、心肌酶谱、血液生化、肝肾功能、血气分析与酸碱平衡、白细胞计数及中性粒细胞分类等项指标达稳定 (或 )平衡时间 ,中西医结合组较对照组明显提前 (P<0 .0 5 )。结论 :在延续生命支持阶段联合应用生脉注射液和护心通注射液 ,有维护心脏和循环功能、提高心肺脑复苏成功率的良好疗效。Objective: To observe the curative effect of integrated traditional Chinese and western medicine(TCM WM) on protecting the heart function and circulation state in the prolonged life support(PLS) phase of cardiac pulmonary resuscitation(CPR), in order to increase the successful rate of cardiac pulmonary cerebral resuscitation(CPCR). Methods: Sixtynine cases of heart beat recovered from cardiac arrest(CA) gone through CPR were randomly divided into two groups, 35 cases in TCM WM group and 34 cases in control group. The patients in two groups were treated with common therapeutics based on the CPR and (emergency) cardiovascular care guidelines 2000, and Shengmai injection(生脉注射液)+creatine phosphate(CP) were (intravenously) drip once a day for 37 days in the early period of PLS phase in the TCM WM group. (Results): (①The) successful rate of CPR was highest in patients with CPR started within 5 minutes,the second was at (610 minutes). The successful rate of TCM WM group at each time was higher than that of control group. At (1115 minutes) no one successful resuscitate in control group. ② The successful rate of CPCR in the TCM WM group after CA of various factors was 63%(22/35 cases), it was significantly higher than that of (control) (group)(32%, 11/34 cases), P<0.01. ③The time of achieving stable or balanced state of every (observed) (indexes), including heart rhythm, mean artery pressure, maxium index of oxygen consumption, (cardiac) (enzymology), blood chemical composition, liver and renal function, blood gas anaysis, acid and basic (balance), (white) (blood) cell count and neutrophil classification, was markedly shorter in TCM WM group than (that) in (control) (group)((P<0.05)). Conclusion: Shengmai injection +CP using in the PLS phase has obviously (therapeutic) (efficiency) for protecting the heart function and circulation state, and may increase the (successful) (rate) of (CPCR).

关 键 词：心搏骤停 心肺脑复苏 中西医结合治疗 成功率 

分 类 号：R459.7[医药卫生—急诊医学]