细菌感染性疾病患儿血清瘦素、肿瘤坏死因子的改变及意义  

The changes of serum leptin concentrations during infections disease with bacteria in children

作　　者：程玉先[1] 常久利[1] 李雨生[1] 李堂[1] 

机构地区：[1]青岛大学医学院附属医院

出　　处：《山东医药》2004年第19期6-7,共2页Shandong Medical Journal

摘　　要：目的　确定瘦素 (L eptin)与细菌感染性疾病的相关性 ,探讨 L eptin改变的调节机制及意义。方法　分别采用免疫放射法 (IRMA)和酶标免疫分析 (EASIA)检测细菌感染性疾病患儿 33例急性期和恢复期血清L eptin和肿瘤坏死因子 (TNF- α)水平 ,与对照组比较 ,并对 L eptin和 TNF- α水平进行相关分析。结果　细菌感染性疾病患儿急性期血清 L eptin水平明显低于对照组 (P <0 .0 5 ) ,并且与感染的严重程度有关 ,与 TNF- α水平呈负相关。结论　血清 L eptin的测定对感染严重程度和预后的判断有重要意义 ,对进一步探讨内分泌与免疫网络有一定的参考价值。Objective To affirm the correlation between leptin and infectious diseases(ID) and analyzing the mechanism and significance of the correlation.Methods Leptin and tumor necrosis factor(TNF-α)during acute and recovery phases of the 33 ID patients with bacteria were detected by immunoradiometric assay(IRMA) and enzyme amplified sensitivity immunoassay(EASIA) respectively,and the results were compared with the control group.Leptin and TNF-α levels were analyzed by linear correlation analysis.Results Leptin levels during acute phases were lower than those in the control group(P<0.05),and it was negative correlative with TNF-α and depended on the severity of infection.Conclusion Detecting leptin concentrations has great significance on the judgement of the severity of ID.The results provide objective data for the endocrine and immunological network.

关 键 词：细菌感染性疾病 血清瘦素 肿瘤坏死因子 儿童 

分 类 号：R725.15[医药卫生—儿科]