胃痛宁对胃溃疡大鼠胃组织表皮生长因子及一氧化氮含量的影响  

Study on the Effect of Weitongning on Epidermal Growth Factor and Nitric Oxide Contents in Tissue of Stomach of Rats with Gastric Ulcer

作　　者：郑学刚[1] 张建军[2] 黄云春[1] 张国安[1] 阳兴国[1] 

机构地区：[1]湖北民族学院医学院附属医院,湖北恩施445000 [2]湖北中医学院

出　　处：《中国中西医结合杂志》2004年第6期549-551,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨胃痛宁治疗消化性溃疡的作用机理。方法用冰醋酸制备大鼠慢性胃溃疡模型 ,观察胃痛宁治疗胃溃疡的愈合质量 ,再生黏膜厚度 ,溃疡瘢痕周围组织表皮生长因子 (EGF)及一氧化氮 (NO)含量。结果胃痛宁组再生黏膜厚度 ,胃溃疡瘢痕周围组织EGF及NO含量均高于模型组 (P <0 0 1,P <0 0 5 )。结论胃痛宁能提高溃疡愈合质量 ,提高溃疡瘢痕周围组织EGF及NO含量可能是胃痛宁抗消化性溃疡复发的机理之一。ObjectiveTo study the therapeutic mechanism of Weitongning (WTN) in treating peptic ulcer. MethodsRat model of chronic gastric ulcer induced by galcial acetic acid was used to observe the effect of WTN on the curative quality, thickness of regenerated mucous membrane, epidermal growth factor (EGF) and nitric oxide (NO) contents in scar tissue around the gastric ulcer. ResultsThe thickness of regenerated mucous membrane, EGF and NO contents in peri ulcer scar tissue were higher in the model rats after WTN treatment than that in the untreated model rats (P<0 01 or P<0 05). ConclusionWTN could elevate the quality of ulcer curing, to raise the EGF and NO contents in peri ulcer scar tissue might be one of its mechanisms for preventing relapse of peptic ulcer.

关 键 词：胃痛宁 胃溃疡 大鼠 胃组织 表皮生长因子 一氧化氮 PU 瘢痕 

分 类 号：R285[医药卫生—中药学]