早期再灌注对急性心肌梗死患者血浆脑钠素水平的影响  

The effects of early reperfusion therapy on plasma brain natriuretic peptide levels in patients with acute myocardial infarction

作　　者：杨海波[1] 唐元升[2] 朱兴雷[2] 黄振文[1] 

机构地区：[1]郑州大学第一附属医院心内科,郑州450052 [2]山东省立医院心内科

出　　处：《临床心血管病杂志》2004年第7期401-402,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨早期再灌注对急性心肌梗死 (AMI)患者血浆脑钠素 (BNP)水平的影响。方法 :选择AMI患者 5 6例 ,胸痛发作 12h内成功再灌注者 (38例 )为试验组 ,再灌注失败或未进行再灌注者 (18例 )为对照组。ELISA法测定入院即刻、1、2、7、14、2 8d时血浆BNP水平。结果 :AMI患者血浆BNP水平较正常人明显升高 ;试验组血浆BNP水平呈单峰曲线 ,对照组呈双峰曲线 ;再灌注可明显降低AMI患者BNP水平 ,第 7天时浓度升高不明显 ,未形成第 2个高峰。结论 :早期再灌注可明显降低血浆BNP水平。Objective:To investigate the effect of early reperfusion therapy on plasma brain natriuretic peptide (BNP) levels in patients with acute myocardial infarction (AMI).Method:The study group included 56 patients with AMI, 38 patients undergone successful early reperfusion as the test group, 18 patients undergone non-successful or rejected reperfusion as the control group. Peripheral blood samples were taken at admission, on 1,2,7,14 and 28 day after admission for BNP measured by ELISA.Result:Plasma BNP levels in patients with AMI were higher than those in health. In test group, only one peak of BNP values was detected on 24 hours after admission, but two peaks of BNP values were detected in control group, the first peak on 24 hours and secondary peak on 7 day after admission.Conclsion:Early reperfusion therapy can decrease BNP levels.

关 键 词：心肌梗死 心肌再灌注 左室重塑 脑钠素 

分 类 号：R541.1[医药卫生—心血管疾病]