KF-Al_2O_3催化下α-三唑基片呐酮与对氯苯甲醛的缩合反应  

Study of Knoevenagel reaction for α-triazolylpinacolone with 4-chlorophenyl acetaldehyde using catalyst KF-Al_2O_3

作　　者：廖戎[1] 岑贵俐[1] 李国伟[1] 

机构地区：[1]西南民族大学化学与环境保护工程学院,四川成都610041

出　　处：《化学研究与应用》2004年第4期537-538,共2页Chemical Research and Application

摘　　要：We synthesized vinylieriazolyl ketone through Knoevenagel reaction of α-triazolylpinacolone with 4-chlorophenyl acetaldehyde using KF-Al2O3 as a catalyst. The effect of the reaction conditions, such as the amount of catalyst, temperature, the molar ratio of 4-chlorophenyl acetaldehyde to α-triazolylpinacolone and different PEGs was investigated. The optimum reaction conditions are: the molar ratio of 4-chlorophenyl acetaldehyde to α-triazolylpinacolone is 1.2∶1, reaction time is 0.5 h, reaction temperature is 75～80℃, the phase transfer is PEG4000. Under these conditions, the yield of vinylieriazolyl ketone could reach up to 95.2%.We synthesized vinylieriazolyl ketone through Knoevenagel reaction of α-triazolylpinacolone with 4-chlorophenyl acetaldehyde using KF-Al_2O_3 as a catalyst. The effect of the reaction conditions, such as the amount of catalyst, temperature, the molar ratio of 4-chlorophenyl acetaldehyde to α-triazolylpinacolone and different PEGs was investigated. The optimum reaction conditions are: the molar ratio of 4-chlorophenyl acetaldehyde to α-triazolylpinacolone is 1.2∶1, reaction time is 0.5 h, reaction temperature is 75～80℃, the phase transfer is PEG4000. Under these conditions, the yield of vinylieriazolyl ketone could reach up to 95.2%.

关 键 词：KF-Al2O3试剂 相转移催化 KNOEVENAGEL反应 

分 类 号：O621.7[理学—有机化学]