大鼠长期饮用氚水的致癌效应研究  

STUDY ON THE CARCINOGENIC EFFECT OF LONG-TERM DRINKING TRITIATED WATER IN RATS

作　　者：邹淑爱[1] 李茂河[1] 王蕙[1] 蔺素琴[1] 

机构地区：[1]中国辐射防护研究院,太原030006

出　　处：《辐射防护》1993年第1期64-67,71,共5页Radiation Protection

摘　　要：本文观察了S.D.大鼠长期(1.5年)饮用低浓度氚水后的肿瘤发生情况。实验分3组:对照组、1.11×10~5Bq/mL组和2.22×10~4Bq/mL组。结果表明,大鼠长期饮用氚水1.5年后,对照组、1.11×10~5Bq/mL 组和2.22×10~5Bq/mL 组的肿瘤发生率分别为22.5%、30.4%和56.0%,其中恶性肿瘤的发生率分别为7.5%、6.5%和34%。经 X^2检验,2.22×10~5Bq/mL 组的肿瘤发生率明显高于1.11×10~5Bq/mL组(p<0.05)和对照组(p<0.01),恶性肿瘤发生率也明显高于1.11×10~5Bq/mL 组(p<0.01)和对照组(p<0.01);2.22×10~5Bq/mL 组动物的肿瘤出现时间比1.11×10~5Bq/mL 组早200 d 左右;恶性肿瘤中以纤维肉瘤、腺癌为多见,其次为白血病和横纹肌肉瘤,良性肿瘤以纤维瘤和腺瘤多见。Induction of tumours was seek in rats drinking water with low dose of tritium for 1.5years.For rats drinking water with 2.22×10~5 Bq of tritiurn/mL(high dose-rate group),the totalturmour incidence was found to be 56% and the malignant tumour incidence to be 34%,for ratsdrinking water with 1.11×10~5 Bq of tritium/mL(low dose-rate group),they were found to be 34and 6.5%,respectively,and for control rats which drinked tap water,these parameters were 22.5and 7.5%,respectively.In the high dose-rate group,more rats(20%)with two types of tumours was observated than in the low dose-rate group(with a frequency of 8.6%).Differences in the totaltumour incidence and in the malignant tumour incidence between high and low dose-rate groups werestatistically significant.For the high dose-rate group,tumours appear about 200 days more early thanthat for the low dose-group.In malignant tumours,fibrosarcoma and adenocarcinoma were more frequent and leukemia,andrhabdomyosarcoma were less.Fibroma and adenoma were frequent benign tumours in thisexperiment.

关 键 词：致癌效应 氚 生物效应 肿瘤 

分 类 号：Q691.4[生物学—生物物理学]