微波辐射应用于β,β'-联萘酚的合成与拆分  

Synthesis of BINOL under Microwave Radiation and Its Optical Resolution

作　　者：丁盈红[1] 廖九忠 张广文[1] 梁香[1] 

机构地区：[1]广东药学院药学系,广东广州510224 [2]深圳市龙岗横岗镇人民医院,广东深圳518039

出　　处：《化学世界》2004年第8期430-432,406,共4页Chemical World

摘　　要：微波辐射条件下,FeCl3作催化剂,在水溶液中由2-萘酚制得外消旋β,β'-联萘酚(BINOL),反应最佳条件为:微波功率330W,时间2min,产率90%。应用微波合成的拆分剂N-苄基氯化辛可宁拆分了上述外消旋联萘酚,比较了微波状态下的拆分结果与常规加热条件下的拆分结果。微波条件下,不能显著缩短拆分回流时间。The oxidative coupling of 2-naphthols suspended in aqueous solution containing Fe^(3+) under microwave radiation gives corresponding BINOL with the yield of 90%. The optical resolution of BINOL has been made with (+)-N-benzylcinchoninium chloride with the yield of 53% under microwave radiatio. The resolution results under microwave radiation and traditional condition are compared.

关 键 词：β β'-联萘酚 微波辐射 拆分 

分 类 号：O626[理学—有机化学]