皮肤和骨移植物辐照生物效应的研究  

STUDY ON THE BIOLOGICAL EFFECT OF RADIATION ON THE SKIN AND BONE GRAFTS

作　　者：孙世荃[1] 刘赫臣 石占城[1] 刘胜恩 孟宪钰[1] 赵素色[1] 王晨亮[1] 尤占云[1] 熊金莲[1] 贺俊绮 

机构地区：[1]中国辐射防护研究院,太原030006

出　　处：《辐射研究与辐射工艺学报》1993年第2期121-125,共5页Journal of Radiation Research and Radiation Processing

基　　金：国际原子能机构IAEA提供资助(1985--1991);合同号4289/RB

摘　　要：辐照灭菌可以引起皮肤和骨移植物中胶原和粘多糖的退变,使其生物学稳定性和生物活性降低。选择最适辐照灭菌剂量需要权衡其对组织破坏作用的可容忍水平,与其对微生物杀灭作用的可信赖程度。研究结果说明在尽量减少初始菌量的通常无菌操作条件下,15 kGy是可以同时满足上述两个要求的最适辐照剂量。皮肤和骨移植物的戊二醛预处理,有助于改善辐照引起的真皮和骨基质的生物学不稳定性,有助于减少辐照灭菌皮肤和骨移植物临床应用过程中经常遇到的过度吸收现象。Radiation sterilization will induce degradation of col lagen and proteoglycans in the skin and bone grafts. Dose choice of radiation steril izationis decided by the balace of the reliable sterilization to the microorganisms the andtolerable destruction to the graft. The present research supports that 15 kGy isoptimal dose to fulfill both the above requiremerits. provided that skin and bonegrafts are prepared under sterile working condition with feasible caution to diminishthe initial bioburden as far as possible. Glutaraldehyde pretreatment of skin andbone grafts was proposed for overcoming radiation induced degradation of dermalcollagen and bone matrix and it is hopeful for restraining the exaggerated resorp-tion of radiation sterilized AAA bones.

关 键 词：辐射灭菌 骨 皮肤 移植物 辐射效应 

分 类 号：R622[医药卫生—整形外科]