单次注入氚水后氚在孕鼠体内的代谢和转移  

METABOLISM DISTRIBUTION AND TRANSFER OF TRITIUM IN PREGNANT MICE AFTER EXPOSURE TO TRITWM WATER

作　　者：吕慧敏[1] 周湘艳[1] 李莉 张志兴 

机构地区：[1]卫生部工业卫生实验所,北京100088

出　　处：《辐射研究与辐射工艺学报》1993年第2期95-98,共4页Journal of Radiation Research and Radiation Processing

摘　　要：妊娠小鼠单次注入氚水后,在分娩后第3.5d活杀,测定了哺乳鼠和仔鼠组织中的氚活度,并估算了仔鼠出生第3.5d时组织中的剂量率和计算了母体氚向仔鼠的转移系数。结果表明,氚进入动物体内后在各组织之间基本上呈均匀分布,仔鼠组织中的氚活度高于哺乳鼠组织中的氚活度。仔鼠的组织剂量率与受照剂量和受照时间有关。三个实验组的转移系数无明显差异,不受照射剂量的影响。但照射时间对转移系数有一定的影响。Tritium water with three kind of different dose was singleinjected intraperitoneally to pregnant mice in tbe various time. The tritiumconcentration in the tissues from mother mice were measured on the 3.5 days aftermother mice parturition. Dose rates in baby mice were estimated, as well as thetransfer coefficient of tritium from mother mice to baby mice calculated based on thetritium concentrations. The results of the experiment showed that tritium was almostuniformly distributed among the tissues after exposure to tritiated water at threeexperimental groups. However, it was found that relative concentrations of tritiumin the baby mice tissues were consistently higher than that in mother mice tissues forthree experimental groups. The relative concentration of tritium in the tissues wasnot affected by the different dose but developing on the exposure time. The resultsof radiation dose rates from baby mice estimation at the end of exposure showedthat the higher radiation dose rates was found in the md to tritiated waterduring 7.5 days. The transfer coefficient of tritium from mother mice into baby mice was almostno different among the three radiation dose groups. The highest transfer coefficientwas observed in mother mice exposed to tritiated water during 16.5 days, howeverit was not found that transfer coefficient were higher in the mother mice exposedto tritiated water during 11.5 days than that of 7.5 days.

关 键 词：代谢 转移 孕鼠 氚化水 生物效应 

分 类 号：Q691.4[生物学—生物物理学]