损毁大鼠杏仁中央核对不同味觉溶液摄入的影响  

EFFECTS OF THE CENTRAL AMYGDALOID NUCLEUS LESIONS ON TASTANTS INTAKE IN RATS

作　　者：康怡[1] 闫剑群[1] 黄涛[1] 

机构地区：[1]西安交通大学医学院生理教研室,陕西西安710061

出　　处：《中国应用生理学杂志》2004年第3期276-279,共4页Chinese Journal of Applied Physiology

基　　金：国家自然科学基金资助项目 ( 3 0 2 70 45 4)

摘　　要：目的 :研究大鼠杏仁中央核在味觉欣快感受中的作用 ,以探讨其在味觉指导下进行摄食行为调节的可能机制。方法 :采用双瓶选择实验 (味觉溶液vs水 ) ,观察电解损毁大鼠双侧CeA后对四种基本味觉溶液摄入的影响。结果 :与对照组相比 ,CeA损毁明显降低了大鼠对 0 .0 3、0 .1和 0 .3mol/L氯化钠溶液 ,0 .0 1、0 .1和 1.0mmol/L柠檬酸溶液及 10、2 0和 5 0 μmol/L盐酸奎宁溶液的摄入 ,且其对相邻浓度的氯化钠、柠檬酸和盐酸奎宁的分辨能力也明显降低。但两组动物总的摄入量 (味觉溶液和水 )在各组实验中均无显著性差异。结论 :CeA损毁可降低大鼠对味觉溶液的摄入 ,但对不同浓度溶液的影响不同。结果提示CeA可能通过影响中枢味觉评估机制 ,改变大鼠对不同味觉刺激的欣快阈值 。Aim: To investigate the effects of central amygdaloid nucleus (CeA) on the evaluation of taste in rats, and explore the mechanisms of the CeA in modulating the feeding behavior. Methods: By using two-bottle choice test, we measured the consumption of serials concentrations of NaCl, citric acid (CA), quinine HCl (QHCl) and sucrose in bilateral CeA lesioned rats, and compared the results to those in sham lesioned rats. Results: The CeA-lesioned rats exhibited a lower preference for NaCl at concentrations of 0.03; 0.1 and 0.3 mol/L, for CA at concentrations of 0.01; 0.1 and 1.0 mmol/L, and for QHCl at 10; 20 and 50 μmol/L, but the pre-(ference) for serials of concentrations of sucrose are similar between two groups. By comparing the intake of adjacent concentrations of sapid solutions, it indicated that CeA-lesioned rats showed a lower distinction between adjacent concentrations of NaCl, CA and QHCl. However, the total consumption (water and tastants) during all the test sessions was not significantly different between two groups of rats. Conclusion: Lesion of CeA decreases the intake of tastants solution, but the effects on different concentrations of solution are different. It suggests that the CeA plays an important role in the normal response to exteroceptive food stimuli through impacting on the assessment of taste and altering the preference threshold of gustatory stimuli.

关 键 词：杏仁中央核 电损毁 欣快反应 大鼠 

分 类 号：Q434[生物学—生理学]