CD4^+T细胞分化与表观遗传作用  

The Relationships between CD4^+T Cell Differentiation and Epigenetic Regulation

作　　者：江阳[1] 

机构地区：[1]上海第二医科大学免疫学教研室,上海200025

出　　处：《细胞生物学杂志》2004年第4期336-338,共3页Chinese Journal of Cell Biology

摘　　要：DNA甲基化、染色质重塑等表观遗传作用对CD4+T细胞向Th1和Th2的分化有重要的影响,现对Th1细胞表达IFN-γ以及Th2细胞表达IL-4／IL-13在基因转录水平的调节作用给予概述,重点阐述相关转录因子、酶以及蛋白质复合物所发挥的表观遗传调节作用的可能机制。The epigenetic regulation, such as genomic methylation, chromatin remodeling or histone deacetylation, has great influence on the maturation of CD4+T helper cells into Th1 phenotype or Th2 phenotype. In this paper, epigenetic regulation of IFN-γ and IL-4/IL-13 loci in Th1/Th2 cells has been reviewed in some detail. It will help to understand the possible role of the correlated transcription factors, enzymes or multiprotein complex in this epigenetic regulation.

关 键 词：表观遗传 甲基化 CD4^+T细胞 细胞分化 染色质 

分 类 号：Q343[生物学—遗传学]