核内不均一核糖核蛋白在前体mRNA加工中的功能  

The Function of Heterogeneous Nuclear Ribonucleoproteins in pre-mRNA Processing

作　　者：黄嘉[1] 陈献华[1] 徐平[1] 

机构地区：[1]复旦大学生命科学学院基因生理学研究室脑研究中心,上海200433

出　　处：《细胞生物学杂志》2004年第4期377-380,共4页Chinese Journal of Cell Biology

摘　　要：核内不均一核糖核蛋白(hnRNP)是一类存在于真核生物体内具有类似结构特征的高丰度RNA结合蛋白,一般均匀分布在核内。多种hnRNP具有多样的功能,参与从转录调节,前体mRNA剪接,mRNA输出到mRNA降解等多种生物过程,从而进行基因表达调控。现着重介绍hnRNP在前体mRNA加工过程(加帽,剪接,加尾,输出,选择性降解)中的功能及研究进展。Heterogeneous nuclear ribonucleoprotein (hnRNP) is a family of proteins that are highly expressed in eukaryotic cells and diffusely distributed in the nucleus. Various hnRNP proteins share similar structural characteristics and play a variety of functions in regulation of gene expression, including transcription, pre-mRNA splicing, mRNA export and mRNA decay. In this review, we briefly summarize the recent progresses regarding the function of hnRNP in pre-mRNA processing.

关 键 词：核内不均一核糖核蛋白 HNRNP RNA结合蛋白 基因表达 生物学功能 

分 类 号：Q78[生物学—分子生物学]