黄嘌呤氧化还原酶的结构、功能和作用  

The Structure and Function of Xanthine Oxidoreductase

作　　者：李丽书[1] 陈献华[1] 邵叶波[2] 刘璇[1] 徐平[1] 

机构地区：[1]复旦大学生命科学学院基因生理学实验室脑研究中心,上海200433 [2]复旦大学上海医学院,上海200032

出　　处：《细胞生物学杂志》2004年第4期381-384,共4页Chinese Journal of Cell Biology

摘　　要：黄嘌呤氧化还原酶(XOR)参与人体内的嘌呤代谢,并且是这一代谢过程的限速酶。其终产物是活性氧(包括OH·、H2O2和O2-)和尿酸。这两种产物参与体内多种生理活动。从XOR基因的结构、XOR蛋白的分子结构和基本功能、控制XOR活性的多个环节以及XOR的两种催化产物活性氧和尿酸在生理和病理情况下的功能及机制进行了总结,以期对XOR的发现、研究历史及现状和有待解决的问题有一个系统的了解。Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in the catabolism of purines. Thetwo final products of the reaction-uric acid and reactive oxygen species (OH, H2O2and O2) play importantroles in variety physiological processes. In this review, we summarized some important results about XOR, including the genomic sequence, the molecular structure and the function of its protein, multiple steps in regulation of itsactivity, and the function of the two catalytic products-uric acid and reactive oxygen species in physiologicaland pathological conditions. This will help systematically understanding the research history of the enzyme, the situation of recent studies and the problems remains to be resolved.

关 键 词：黄嘌呤氧化还原酶 尿酸 生理 嘌呤代谢 活性氧 

分 类 号：Q55[生物学—生物化学]