上皮细胞转分化的信号转导研究进展及其在肾小管的研究现状  

Signal Transduction on Transdifferentiation of Renal Tubular Epithelial Cell

作　　者：张梅[1] 李晓玫[1] 

机构地区：[1]北京大学第一医院肾内科,北京大学肾脏病研究所北京100034

出　　处：《生理科学进展》2004年第3期219-223,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金资助课题 (30 0 70 35 1)

摘　　要：上皮细胞在特定生理和病理情况下向间充质细胞转分化的现象是肿瘤及慢性炎症性疾病中的重要细胞生物学现象。近年来研究发现 ,细胞内信号转导途径中的MAPK通路、Rho家族激酶、Src激酶、PI3激酶和Smad通路参与调控上皮细胞转分化过程。肾小管上皮细胞在病理条件下可转分化为肌成纤维细胞 ,其细胞内信号转导机制虽已有初步研究 ,但尚所知甚少。It is an important cell biological phenomenon that epithelial cells transit into mesenchymal cells under special physiological and pathological condition. In recent years, it has been known that epithelial-mesenchymal-transition may be mediated by several intracellular signaling pathways, such as MAPK, Rho, Src, PI 3 kinase and Smads. Renal tubular epithelial cells have been observed to transit to myo-fibroblasts in renal diseases. However, the intracellular signaling pathways are rarely known. The progress on this field is reviewed.

关 键 词：上皮细胞 转分化 信号转导 肾小管 间充质细胞 肿瘤 慢性炎症性疾病 

分 类 号：R329.24[医药卫生—人体解剖和组织胚胎学]