N-(4,4'-二氟苯甲基)哌嗪的合成  

Synthesis of N-(4,4'-Difluorobenzhydryl)piperazine

作　　者：唐龙骞[1] 孟昭力[1] 赵彦伟[1] 

机构地区：[1]山东大学药学院,山东济南250012

出　　处：《中国医药工业杂志》2004年第6期331-331,共1页Chinese Journal of Pharmaceuticals

摘　　要：N-(4,4’-Difluorobenzhydryl)piperazine, a key intermediate of lomerizine hydrochloride, was synthe-sized from piperazine hydrochloride via neutralization and condensation with 4,4’-difluorobenzhydrylchloride with an overallyield of 70.4%。N-(4,4'-Difluorobenzhydryl)piperazine, a key intermediate of lomerizine hydrochloride, was synthe-sized from piperazine hydrochloride via neutralization and condensation with 4,4'-difluorobenzhydrylchloride with an overallyield of 70.4%。

关 键 词：N-(4 4’-二氟苯甲基)哌嗪 合成 偏头痛治疗药 盐酸洛美利嗪 

分 类 号：TQ460.31[化学工程—制药化工]