机采血小板后献血者血小板恢复情况探讨  

The recovery of donor′s platelet counts after plateletapheresis

作　　者：刘军[1] 陆宽正[1] 刘静[1] 金宗骧[1] 

机构地区：[1]天津市血液中心,300110

出　　处：《临床输血与检验》2004年第3期169-171,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的　探讨 Amicus血细胞分离机采集单剂量、双剂量血小板对健康献血者血小板计数的影响。方法　应用Amicus血细胞分离机在 2 .5版本操作软件的支持下采集血小板。单剂量组 2 2例 ,设定采集量 3 .0× 1 0 1 1 /L,双剂量组 3 1例 ,设定采集量 6.0× 1 0 1 1 /L。分别观察献血者采前、采后及采集 1个月后献血者的血小板计数值。结果　单剂量组、双剂量组采集血小板量分别为 ( 2 .86± 2 .3 9)× 1 0 1 1 /L、( 5 .75± 4.46)× 1 0 1 1 /L。单剂量组采集前血小板量 [( 2 1 1 .64± 2 1 .2 7)× 1 0 9/L ]显著高于采集后 [( 1 3 5 .73± 2 0 .94)× 1 0 9/L]( P<0 .0 5 ) ;双剂量组采集前血小板量 [( 2 70 .2 6± 3 7.2 5 )× 1 0 9/L ]亦显著高于采集后 [( 1 41 .3 9± 3 9.2 8)× 1 0 9/L]( P<0 .0 5 )。单剂量组、双剂量组的献血者血小板计数较采集前分别下降 3 5 .0 %±1 2 .6%、47.9%± 1 5 .9%。采后 1个月单剂量组献血者血小板回升为 ( 2 1 5 .86± 2 4.5 6)× 1 0 9/L,而双剂量组回升为 [( 2 60 .3 2±3 8.71 )× 1 0 9/L],与采前比较差异有显著性 ( P<0 .0 5 )。　结论　单剂量组机采血小板对献血者健康和血小板制品质量无不良影响。建议双剂量组应提高献血者采前血小板底限值 ( >2 5 0× 1 0Objective To investigate the effects on healthy donor′s platelet counts after single and double apheresis platelets (APs) by the Amicus separator. Methods The platelet concentrates were collected by the Amicus with the Version 2.5 software (Baxter-Fenwal). The target endpoints were set at 3.0×10 11 /Lfor single APs(n=22) and 6.0×10 11 /Lfor double APs (n=31). The changes in donor′s platelet counts were determined at pre- and post- donation and one month later. Results The platelet yields for the single and double APs were (2.86±2.39)×10 11 /Land (5.75±4.46)×10 11 /Lrespectively. The changes of platelet counts on donors in pre- and post- donation were significant between ( 211.64 ±21.27)×10 9/Land(135.73±20.94)×10 9/L(P<0.05)forthesingleAPs,between(270.26±37.25)×10 9/L and(141.39±39.28)×10 9/L(P<0.05) for the double(APs),respectively. The platelet counts of donors for the single and double APs in post-donation rates of platelet decreased more than that in pre-donation by 35.0%±12.6% and 47.9%±15.9%, respectively. After donation of one month, the platelet counts of donors for the single and double APs elevated to (215.86±24.56)×10 9/L,(260.32±38.71)×10 9/L respectively, but in double APs the platelet counts were lower in post-donation than that in pre-donation significantly (P<0.05). Conclusion The baseline platelet values of donors for single APs in pre-donation do not influence the quality of platelets and have no adverse effects on the donors′ health. It had been recommend that baseline platelet counts of donors for double APs in pre-donation should be >250×10 9/L, which will reduce the rates of the post-donation values of platelet counts to <100×10 9/L, and increase the recovery rate to the pre-donation values of platelet counts after one month.

关 键 词：机采血小板 献血者 血小板恢复 

分 类 号：R331.1[医药卫生—人体生理学] R193.3[医药卫生—基础医学]