肝素防治产科播散性血管内凝血的临床观察  

The clinical observation of heparin used to prevent and cure the disseminated intravascular coagulation in patients with obsterical deseases

作　　者：刘楚芹 李奇艳[1] 

机构地区：[1]广东肇庆市第二人民医院妇产科,526060

出　　处：《中国基层医药》2004年第6期677-678,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨肝素在防治产科播散性血管内凝血 (DIC)中的作用。方法　对收治的DIC、重度妊娠高血压综合征 (重度妊高征 )、过期流产共 132例进行临床总结分析。结果　DIC使用肝素 18例 ,死亡率5 5 6 % (1/ 18) ;对照组中 ,重度妊高征发生DIC 2例 ,发生率为 14 2 9% (2 / 14 ) ,死亡 1例 ;过期流产发生DIC3例 ,发生率为 18 75 % (3/ 18)。肝素组中 ,重度妊高征、过期流产均无DIC发生。结论　肝素作用于凝血过程的多个环节 ,根据DIC、重度妊高征、过期流产的病因及病理生理 ,肝素可作为主要的治疗手段 ;治疗DIC以少量多次使用为主 ,预防DIC则为 2 5mg/d。Objective To study the function of heparin which is used to prevent and cure the disseminated intravascular coagulation(DIC) in patients with obsterical diseases.Methods 132 patients who have DIC or severe pregnancy-induced hypertension syndrome or missed abortion,the number of patients were analysed.Results In heparin treated group,death rate was 5.56% in patients with DIC,DIC didn't occur in patients with severe pregnancy-induced hypertension or missed obortion;but in control group,two patients developed DIC and one died in 14 patients with severe pregnancy-induced hypertension,three patients had DIC in 18 patients with missed abortion.Conclusions Dur data indicates that heparin can prevent and treat DIC and reduce the mortality rate induced by obsterical diseases suche as servere pregnancy-induced hypertension or missed obortion.

关 键 词：肝素 产科并发症 播散性血管内凝血 预防 治疗 重度妊娠高血压综合征 过期流产 

分 类 号：R714.4[医药卫生—妇产科学]