β-环糊精球的制备及其药物控释行为研究  

Study on preparation of β-cyclodextrin beads and their behavior of controlled drug release

作　　者：严春美[1] 刘郁杨[1] 范晓东[1] 

机构地区：[1]西北工业大学理学院应用化学系,西安710072

出　　处：《化工新型材料》2004年第6期39-42,共4页New Chemical Materials

基　　金：陕西省自然科学基金 (2 0 0 0H1 1 );西北工业大学本科生毕业论文创新基金资助

摘　　要：　以 β 环糊精 (β CD)和环氧氯丙烷 (EPI)为原料 ,利用反相聚合技术成功地制备出了药物控释载体 β CD球 ,研究了制备过程的工艺参数对合成 β CD球的影响。用抗癌药物金雀异黄素(GNT)作为模型药物 ,采用紫外可见分光光度计研究了 β CD对GNT的包合作用。结果表明 ,在 pH=1 4和 pH =7 4下 ,β CD可与GNT形成n(β CD) /n(GNT) =1的包合物 ,包合常数Ka分别为2 6 9× 10 3L·mol- 1和 9 0 4× 10 2 L·mol- 1。β CD球对GNT的控制释放研究结果表明 ,GNT的释放速率存在明显的零级释放规律 ,且 pH =7 4下的释放速率明显快于 pH =1Cyclodextrin (β-CD) beads, which were used as a drug carrier, were prepared by the reaction of β-CD with EPI using technique of inverse polymerization. And related preparation conditions were investigated and optimized. In order to evaluate the carrier's behavior of controlled drug release, using genistein(GNT), an anti-cancer medicine, as a model medicine, inclusion complex between β-CD and GNT were firstly investigated by UV spectra. The results indicated that inclusion compounds of β-CD and GNT with 1∶1 molar ratio were formed under the condition of pHs 1.4 and 7 4, with corresponding stability constants of 2 69×10 3 L·mol -1 and 9 04×10 2 L·mol -1,respectively. Then, the release behaviors of GNT in β-CD beads were studied. Results showed that the release rate of GNT kept almost constant after 24h independent of their sizes, and release rate of GNT was higher at pH 7 4 than that of at pH 1 4.

关 键 词：β-环糊精球 环氧氯丙烷 反相聚合 金雀异黄素 紫外可见分光光度计 包合物 控制释放 智能给药 

分 类 号：TQ460[化学工程—制药化工]