^(153)钐-乙二胺四亚甲基膦酸联合甲孕酮治疗多发性骨转移癌骨痛32例  

Treatment of 32 cases of bone pain of metastatic multi-cancer with (153)~Sm-EDTMP in combination with MPA

作　　者：王晓红[1] 郭晓光[1] 雷霞[1] 毋永娟[1] 刘姣林 鲍力[1] 梁秀芳[1] 李丽清[1] 韩爱玲[1] 弓素梅[2] 

机构地区：[1]内蒙古包头市第七医院化疗科,包头014030 [2]包头市职业技术学院医务所,包头014030

出　　处：《中国新药杂志》2004年第6期559-562,共4页Chinese Journal of New Drugs

基　　金：包头市医药卫生发展基金会资助项目(2003G2136-7)

摘　　要：目的:观察153钐-乙二胺四亚甲基膦酸(153Sm-EDTMP)联合甲孕酮(MPA)治疗多发性骨转移癌骨痛疗效、不良反应及对生活质量的影响。方法:入选32例,采用153Sm-EDTMP内照射联合MPA治疗。153Sm-EDTMP用法为2.96×107～3.70×107Bq·kg-1静注,4-6周用药1次,MPA 500mg·d-1,连用14d为1个疗程,共1～2个疗程。结果:完全缓解(CR)17例,部分缓解(PR)9例,缓解骨痛总有效为26例,对前列腺癌和乳腺癌骨转移患者 的有效率达到90%,患者的生活质量明显提高。主要不良反应为白细胞和血小板的轻、中度降低。结论:应用153 Sm-EDTMP联合MPA治疗多发性骨转移癌骨痛有效,不良反应小。Objective: To observe the ADRs and efficacy of 153Sm-EDTMP combined with MPA in treatment of bone pain in metastatic cancer patients. Methods: 32 patients were taken part in this study. They were treated with intravenous injection of 153Sm-EDTMP in a dose of 2.96×107-3.70×107Bq·kg-1 once each 4-6 weeks combined with MPA in a dose of 500mg·d-1. A therapeutic circle consisted of 14 consecutive days and 2 circles were needed. Results: The bone pain in 17 patients were completely relieved,9 patients were partially relieved and totally 26 patients were relieved.The effec-tive rate was up to 90% for bone pain in patients with prostate cancer and breast cancer. The quality of life in patients was signif icantly improved. The ADRs observed were mainly slight decrease in WBC and platelets.Conclusion:153Sm-EDTMP combined with MPA can be used as a therapeutic measure for treatment bone pain of metastatic multi-cancer with mild adverse drug reaction.

关 键 词：骨转移癌 ^153钐—乙二胺四亚甲基膦酸 甲孕酮 骨痛 

分 类 号：R971[医药卫生—药品] R969.4[医药卫生—药学]