血液透析患者血清铜兰蛋白与钙磷代谢及继发性甲状旁腺功能亢进  

The relationship between serum ceruloplasmin,calcium and phosphorus metabolism and secondary hyperparathyroidism in hemodialysis patients

作　　者：王悦[1] 阿拉塔[1] 梁力均[1] 史钧宝[1] 张爱华[1] 朱宁[1] 范敏华[1] 

机构地区：[1]北京大学第三医院肾内科,北京100083

出　　处：《中国血液净化》2004年第7期374-376,共3页Chinese Journal of Blood Purification

摘　　要：目的　探讨维持性血液透析患者血清铜兰蛋白与钙磷代谢及继发性甲状旁腺功能亢进之间的关系。方法　检测 6 8例维持性血液透析患者血清铜兰蛋白、血清磷、血清钙、血清全段甲状旁腺激素(PTH)水平 ,分析铜兰蛋白与后三者及钙磷乘积之间的相互关系。结果　与正常人相比 ,透析患者血清铜兰蛋白显著增高 ,血清钙显著降低 ,血清磷和甲状旁腺激素显著增高 ;血清钙与铜兰蛋白水平呈显著负相关 ,血清磷和甲状旁腺激素与铜兰蛋白水平呈显著正相关。结论　血清铜兰蛋白可能参与透析患者体内钙磷代谢紊乱、继发性甲状旁腺功能亢进和肾性骨病的发生。Objective To investigate the level of serum ceruloplasmin in hemodialysis patients and the relationship between serum ceruloplasmin, calcium and phosphorus metabolism and secondary hyperparathyroidism. Methods Serum ceruloplasmin, serum calcium, phosphorus and parathyroid hormone (PTH) of 68 hemodialysis patients and 50 healthy controls were tested and the relation ship between serum ceruloplasmin and serum calcium, phosphorus, multiplication of calcium and phosphorus, PTH were analyzed. Results The level of serum ceruloplasmin was higher in hemodialysis patients with (787.6±248.6)active unit/dl than (376.5±146.7)active unit/dl in healthy controls, P<0.05. The longer of the hemodialysis time, the patients had the higher of the serum ceruloplasmin with was (825.3±286.7) avtive unit/dl in patients who underwent over two-year hemodialysis yet it was (598.5±186.4)active unit/dl in patients less than two-year hemodialysis, P<0.05. Serum calcium were lower in hemodialysis patients than in healthy controls, P<0.05, and there was a significant negative relation between serum calcium and ceruloplasmin, P<0.05; serum phosphorus and PTH were higher in hemodialysis patients than in healthy controls, P<0.05, and there was a significant positive relation between them and serum ceruloplasmin, P<0.05. Conclusions Serum ceruloplasmin in hemodialysis patients may have some relation with calcium and phosphorus metabolism disorder and secondary hyperparathyroidism.

关 键 词：透析患者 铜兰蛋白 钙磷代谢 继发性甲状旁腺功能亢进 

分 类 号：R446.6[医药卫生—诊断学]