儿童病毒性脑炎62例临床及病毒病原学分析  

Clinical analysis and pathogenic study on 62 cases of encephalitis in childhood

作　　者：蔡虹[1] 王立文[1] 朱彦丽[1] 吕凌云[1] 徐光芝[1] 朱汝南[1] 邓洁[1] 赵林清[1] 钱渊[1] 

机构地区：[1]首都儿科研究所,北京100020

出　　处：《中国实用儿科杂志》2004年第7期415-416,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的　探讨不同年龄组儿童病毒性脑炎临床表现差异及脑脊液病毒病原学特点。方法　选取首都儿科研究所2 0 0 2年 1月至 2 0 0 3年 2月收治的 6 2例病毒性脑炎患儿 ,根据年龄分为A组 ( <3岁 )、B组 ( 3～ 6岁 )、C组 ( >6岁 ) 3组。 ( 1)分析不同年龄组临床表现特点。 ( 2 )应用多重引物PCR方法对脑脊液进行病毒病原学检测 ,包括肠道病毒 (EV)、疱疹病毒 (HSV)Ⅰ、Ⅱ型、EB病毒、巨细胞病毒 (CMV) 5种。结果　 ( 1) 3组患儿均有发热、嗜睡、烦躁、淡漠等症状 ;其他伴随症状 :A、B两组患儿中 2 4例 ( 6 2 5 % )伴有惊厥 ,C组中 2 2例 ( 95 7% )伴随头痛。 ( 2 )脑脊液病毒病原检测阳性者 39例 ( 6 2 9% ) ,其中EV 18例 ( 4 6 2 % ) ,HSVⅡ型 9例 ( 2 3 1% ) ,CMV、EB病毒各 6例 (各 15 4 % ) ,HSVⅠ型未检出。结论　 ( 1)除发热、嗜睡以外不同年龄组病毒性脑炎患儿伴随症状不同。 ( 2 )Objective To investigate the difference of clinical manifestation among different groups of age in childhood and probe into pathogenic characteristics in CSF.Methods (1)Analyze the clinical manifestations among the different groups of age.(2)The DNA or RNA of EV、HSV Ⅰ、HSV Ⅱ、CMV、EB were determined by PCR in the cerebrospinal fluid(CSF) in 62 cases of encephalitis in childhood.Results (1)The clinical manifestations included fever,winking,fret,indifference in three groups.Other accompanying symptoms:24 cases (62 5%) had seizure in group A and B;22 cases (95 7%) had headache in group C.(2)The positive rate of pathogen in CSF was 62 9%(39),in which EV was 46 2% (18), HSV Ⅱ was 23% (9),CMV was 15 4% (6),EB was 15 4% (6).Conclusion (1)The accompanying symptoms are different among different age groups except fever,winking,fret,and indifference.(2)The positive rate is higher to detect pathogen in CSF with PCR in early encephalitis.

关 键 词：病毒性脑炎 临床表现 多重引物PCR法 病毒病原学 

分 类 号：R72[医药卫生—儿科]