新生儿溶血病血型免疫抗体研究  

The study of blood group immunity antibody of newborn hemolytic disease

作　　者：黄道连[1] 王冬娥[2] 王胜岚[2] 万波[3] 曾倩[4] 高建慧[5] 林雪霞[4] 石冬梅[1] 孔庆铸[1] 李丽莲[1] 

机构地区：[1]中山市博爱医院血液室,广东中山528403 [2]中山市博爱医院检验中心 [3]中山市博爱医院产科 [4]中山市博爱医院产房 [5]中山市博爱医院新生儿科

出　　处：《临床血液学杂志》2004年第4期202-203,共2页Journal of Clinical Hematology

基　　金：中山市科技基金 (No :2 0 0 2 0 1)

摘　　要：目的 :探讨ABO血型不合孕妇血清IgG抗A(B)效价及亚型与ABO 新生儿溶血病 (HDN)的关系。方法 :对 16 2 2例O型孕妇血清IgG抗A(B)效价检测及抗体分型、观察药物预防HDN效果。结果 :16 2 2例孕妇血清中IgG抗A(B)效价≥ 1/6 4者 2 4 5例 ,占 15 .1% ,ABO HDN发生率随IgG抗A(B)效价增高而上升 ,中药预防HDN效果显著。结论 :孕妇血清IgG抗A(B)效价≥ 1/6 4须用药物进行预防性治疗 ,IgG抗A(B)效价高低与HDN发病率成正比 ,ABO HDN的抗体亚型以IgG1和IgG2为主。HDN可以预测 ,药物预防安全有效。Objective:To explore relationship between the level of serum antibody anti-A( B) IgG titer and antibody subgroup of pregnant woman with ABO blood group incompatibility and hemolytic disease of newborn(ABO-HDN).Method:The level of blood group antibody anti-A( B) IgG titer and antibody subgroup were examined in 1622 pregnant with O blood group and the effect of medicine prevention of HDN was observed.Result:245 cases of 1622 pregnant women showed the level of serum antibody anti-A( B) IgG titer ≥ 1/64, accounted for 15.1%, The incidence of ABO-HDN increased along with the higher of IgG anti-A( B) titer.The Chinese herbal medicine prevention was effective to HDN.Conclusion:Anti-A( B) IgG titer ≥ 1/64 in Pregnant women should be treated with medcine.The level of blood group immunity antibody of IgG and the incidence of HDN was in proportion. Major ABO-HDN subgroup belong to antibody with IgG1 and IgG2. The HDN can be predicted,Medicine prevention was safe and valid.

关 键 词：红母细胞增多症 胎儿 孕妇 ABO血型 IgG抗A(B)抗体 

分 类 号：R722.18[医药卫生—儿科]