壳聚糖的体外血脂吸附能力及调脂作用观察  

Observation on absorbent function for blood lipid in vitro and effect of chitosan for regulating blood lipid

作　　者：张淑琴[1] 纪凤翔 阚耀东[1] 田丰[2] 

机构地区：[1]天津市第二中心医院检验科,天津市300120 [2]解放军军事医学科学院卫生装备研究所,天津市300161

出　　处：《中国临床康复》2004年第21期4224-4225,i001,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:通过对壳聚糖几种衍生物对血脂的体外吸附实验选择出吸附能力较好的一种进行口服壳聚糖的安全性及调脂观察。方法:壳聚糖服用方式:2g/d,早晚各服1次,连服1个月。测定服用前及服用后停药1周的血脂、肝肾功能、血红蛋白、纤维蛋白原的变化。同时以服脂必妥药物为对照组。结果:电镜观察壳聚糖具有吸附血脂的功能。比较实验组服用壳聚糖前后血红蛋白、纤维蛋白原、肝肾功能,经统计学处理,差异无显著性意义(P>0.05)。实验组服用壳聚糖前后胆固醇、三酰甘油、高密度脂蛋白胆固醇均降低,差异有显著性意义(P<0.01)。临床应用有效率与对照组比较胆固醇、三酰甘油、高密度脂蛋白胆固醇,差异无显著性意义(P>0.05)。结论:壳聚糖对于胆固醇、三酰甘油、高密度脂蛋白胆固醇具有调节功效。AIM:To observe the reliability and the effect of oral chitosans in regulating the level of blood lipid with better sorption by adsorption experiment in vitro of the derivative of chitosans. METHODS:Ways of taking chitosans:2 g per day,twice a day for a month,the changes of blood lipid,hepatic and renal function,blood pigment,fibrinogen were determined before and 1 week after taking medicine. Meanwhile,subjects taking zhibituo were used as control group. RESULTS:Chitosans had the function of absorption under electron microscope.Comparison of blood pigment,hepatic and renal function and fibrinogen before and after taking chitosans in the experimental group showed no significant difference(P >0.05).After treatment,the levels of cholesterol,triacylglycerol(TG) and high density lipoprotein cholesterol(HDL C) were all significantly decreased(P< 0.01),but there were no significant changes as compared with the control group(P >0.05).CONCLUSION:Chitosan has the regulated effect on cholesterol ,TG and HDLC.

关 键 词：壳聚糖 血脂吸附能力 调脂作用 安全性 胆固醇 三酰甘油 高密度脂蛋白胆固醇 

分 类 号：R977.6[医药卫生—药品]