低冠心病患病率女性人群中体质量指数、腰臀比与总胆固醇、三酰甘油、高密度脂蛋白胆固醇相关性(英文)  

Relationship between body mass index,waistline hipline ratio and total cholesterol,triglyceride,high density lipoprotein cholesterol in the females with low prevalence of coronary heart disease

作　　者：李河 麦劲壮[1] 饶栩栩[1] 李义和[1] 石美玲[1] 刘小清[1] 邓木兰[1] 吴勇[1] 高向民[1] 

机构地区：[1]广东省人民医院心血管病研究所心内科,广东省广州市510080

出　　处：《中国临床康复》2004年第21期4368-4371,共4页Chinese Journal of Clinical Rehabilitation

基　　金：卫生部默沙东基金资助(95-03);中澳合作项目~~

摘　　要：背景:由于危险因素致动脉粥样硬化(atherosclerosisdisease,AS)/冠心病存在协同/交互作用,危险因素常趋向交集(聚集性)及表现以某种组合而导致AS/冠心病,如体质量指数(bodymassindex,BMI)及腰臀比的增加与某些危险因素水平的增高相关,但这些结果主要来源于高AS/冠心病患病率的西方人群。目的:探讨在低AS、低冠心病患病率女性人群中BMI、腰臀比的线性组合与总胆固醇、三酰甘油、高密度脂蛋白胆固醇(highdensitylipoproteincholesterol,HDL-C)的线性组合是否存在更高的相关性及相关特征,以便进一步认识AS/冠心病的危险因素。同时初步探讨血脂指标预测BMI、腰臀比的重要性。设计:横断面调查研究。地点、对象和方法:采用现况研究方法,于1995年对广东省479例女性对象进行调查,所有步骤遵循中澳合作项目研究方案。主要观察指标:479例女性研究对象身高、体质量、腰围、臀围及血脂指标总胆固醇、三酰甘油、HDL-C分析结果。结果:①BMI、腰臀比、总胆固醇、三酰甘油、HDL-C分别为(21.61±3.39)kg/m2,0.80±0.06,(4.24±0.79),(1.13±0.57),(1.31±0.32)mmol/L。②BMI与总胆固醇、三酰甘油呈正相关(r=0.11265,P<0.05;r=0.30519,P<0.01)。BMI与HDL-C呈负相关(r=-0.15809,P<0.01)。腰臀比与总胆固醇、三酰甘油呈正相?BACKGROUND:Since the risk factors tend to reinforce/interact with each other in their influence on atherosclerosis (AS)/coronary heart disease (CHD), risk factors tend to aggregate and usually appear in some combinations to cause the diseases. For example, the elevation of body mass index (BMI) and waistline hipline ratio (WHR) are associated with elevated levels of several vardiovascular risk facotrs, but which was based primarily on data from Western populations living with high prevalence of AS/CHD. OBJECTIVE:To explore whether a linear combination of BMI and WHR had stronger association with a linear combination of recognized risk factor serum lipids total cholesterol (TC),triglyceride (TG) and high density lipoprotein cholesterol (HDL C) in the females with low prevalence of ASD/CHD,so to further recognize the risk factors to AS/CHD.We also hoped to determine the relative importance of serum lipids predicting BMI and WHR. DESIGN:Cross sectional study. SETTING,PARTICIPANTS and INTERVENTIONS:With cross sectional study,479 females were surveyed in 1995 in Guangdong Province,China.All the procedures followed the standards from the China Australia collaboration program.The main study variables:body measurements height,weight,waistline,hipline of 479 female paricipants;and the serum lipids TC,TG and HDL C were analyzed. RESULTS:①The mean of BMI,WHR,TC,TG,HDL C was (21.61 ±3.39) kg/m2,(0.80±0.06),(4.24±0.79),(1.13±0.57),(1.31±0.32) mmol/L,respectively.②BMI was significantly correlated with TC and TG(r=0.11265, P< 0.05; r=0.30519,P< 0.01). BMI was negatively correlated with HDL-C(r=-0.15809,P< 0.01). WHR was significantly correlated with TC and TG (r=0.16969,0.40034, P< 0.01). WHR was negatively correlated with HDL-C(r=-0.12936, P< 0.01).③The canonical correlation coefficient between the body measurements and serum lipids was R1,Can=0.451 050(F=19.49,P< 0.000 1) between V1 and W1(V1=0.287 7×BMI'?0.791 4×WHR' and W1= 0.184 0×TC'?0.881 8×TG'-0.430 0×HDL C').④The standardized stepwise regress

关 键 词：冠心病 患病率 女性 体质量指数 腰臀比 总胆固醇 三酰甘油 高密度脂蛋白胆固醇 危险因素 

分 类 号：R541.4[医药卫生—心血管疾病]