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作 者:金振一[1] 李华[2] 丁大植[1] 秦孝智[1] 崔兰[1] 沈铁宽[1]
机构地区:[1]延边大学医学院附属医院心内科,吉林省延吉市133000 [2]延边朝鲜族自治州药品检验所
出 处:《中国心血管病研究》2004年第8期608-610,共3页Chinese Journal of Cardiovascular Research
摘 要:目的探讨缬沙坦联合培哚普利治疗慢性充血性心力衰竭(CHF)的临床疗效及安全性。方法54例CHF患者,男34例,女20例,平均年龄55岁,心功能Ⅱ~Ⅳ级,平均左室射血分数(LVEF)35.6%,随机分为缬沙坦联合培哚普利的观察组和培哚普利加安慰剂的对照组。缬沙坦40mg/d,培哚普利从小剂量开始使用,只要能耐受,尽可能递增到8~10mg/d。治疗前及治疗12周以后,二组的左心室射血分数(LVEF)、每搏量(SV)、心脏指数(CI)及6min步行距离进行比较。结果二组患者治疗后LVEF、SV、CI及6min步行距离较治疗前显著提高。治疗后观察组LVEF、SV、及6min步行距离较治疗前显著提高。结论与单独应用培哚普利治疗CHF相比,缬沙坦联合培哚普利治疗可显著提高CHF患者活动耐量,改善心功能。Objective To investigate the clinical efficacy and safety of valsartan combined with perindopril in treatment of chronic heart failure(CHF). Methods Fifty-four patients with CHF(male 34,female 20),average age of 55 and average left ventricular ejection fraction(LVEF) 35.6%,were divided randomly into the treatment group(valsartan combined with perindopril) and the control group(perindopril with placebo).The dosage of valsartan was 40mg/d,perindopril titrating from 2mg/d to 8~10mg/d if they were tolerated.LVEF,cardiac index(CI) and distance of 6-minute-walk of the two groups were compared before and after twelve-week treatment. Results LVEF,cardiac index(CI),stoke volume(SV) and distance of 6-minute-walk of the both groups improved significantly after treatment.Furthermore,after treatment,LVEF,CI and distance of 6-minute-walk of the treatment group improved more significantly than those of the control one. Conclusion Exercise capability and cardiac function improved signicantly in the patients treated with valsartan combined with perindopril than those treated with prindopril only.
分 类 号:R541.61[医药卫生—心血管疾病]
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