不同剂量比索洛尔对心功能不全患者的疗效与安全性比较  

Comparison of efficacy and safety of different dose bisoprolol in patients with cardiac dysfunction

作　　者：向群[1] 姚强[1] 阮力[1] 李国军[1] 蒋兰晔[1] 

机构地区：[1]怀化医学高等专科学校附属铁路医院,怀化铁路总公司医院心内科,湖南怀化418000

出　　处：《临床荟萃》2004年第15期848-850,共3页Clinical Focus

摘　　要：目的　研究不同剂量比索洛尔治疗慢性心力衰竭的疗效与药物不良事件。方法　将 14 4例患者按比索洛尔剂量随机分为 2 .5mg组、5mg组和7.5mg以上组 ,对 3组心功能、运动耐受力、心脏事件死亡数、再住院率与药物不良事件数进行比较。结果　高剂量组降低血压、心率、改善患者运动耐受力要优于低剂量组 ,可减少因心脏事件的再住院率 ,同时也增加了药物不良事件发生的几率。结论　高剂量比索洛尔治疗慢性心力衰竭优于低剂量 。Objective To research the effect and drug adverse events of bisoprolol at different dosage. Methods One hundred and fourty-four patients were randomly divided into 2.5 mg group, 5 mg group and 7.5 mg group. Comparisons were done on cardiac function, exercise tolerance, the death occurrence of heart, the rate of rehospitalization and drug adverse events. Results High dosage group was better than low dosage group in the control of blood pressure, heart rate. The exercise tolerance was improved and the rate of rehospitalization was decreased. But the frequency of drug adverse event was also increased. Conclusion High dosage of bisoprolol was superior to low dosage of bisoprolol in the treatment of chronic heart failure. But the frequency of drug adverse reaction was also increased.

关 键 词：比索洛尔 心力衰竭 充血性 心脏功能 疗效 

分 类 号：R541.6[医药卫生—心血管疾病]