肾性高血压大鼠血管反应性增强的探讨  

Study on Mechanisms of Vasocostriction in Renal Hypertensive Rat Vasculars

作　　者：吴秀香[1] 李淑云 马克玲 夏桂兰[1] 

机构地区：[1]锦州医学院病理生理学教研室,辽宁锦州121001 [2]锦州医学院机能中心实验室,辽宁锦州121001

出　　处：《锦州医学院学报》2004年第3期19-20,共2页Journal of Jinzhou Medical College

摘　　要：目的　探讨肾性高血压 (RH)大鼠血管反应性增强的机制。方法　体重为 16 0～ 180 g健康雄性Wistar大鼠随机分成二组 :高血压 (RH)组及对照 (C)组。术后 30d ,用颈动脉直接插管法测定大鼠血压的变化并应用放射免疫等测定技术测定大鼠主动脉组织中ACE及AII的变化。结果　肾性高血压大鼠的主动脉组织中ACE活性及AII含量均明显增高。Objective To study the mechanisms of vasocostriction in renal hypertensive rat vasculars. Methods Male Wistar rats weighing 160～180g were divided into two groups: control (c) group and renal hypertension(RH) group. Blood pressure was measured by inserting a cannula into the carotid artery and ACE activity, AII contents was measured after feeding the rats for 20days.Results The ACE activity, AII contents increase in RH rats . Conclusions The increased vasocostriction in renal hypertensive rat vasculars is related to the increase of rennin-angiotensin system in RH aorta.

关 键 词：肾性高血压 血管 ACE AII 放射免疫 

分 类 号：R544.14[医药卫生—心血管疾病]