心复力冲剂防治心力衰竭作用机理探讨  

Study on Effects of Xinfuli Granula on Caediac Failure in Cats and Rats

作　　者：马丽红[1] 焦增绵[1] 范礼理[2] 阮英茆[1] 王亚芳[2] 司文学[1] 

机构地区：[1]中国医学科学院阜外心血管病医院,北京100037 [2]中国医学科学院药物研究所

出　　处：《医学研究通讯》2004年第7期41-43,共3页Bulletin of Medical Research

摘　　要：目的探讨心复力冲剂防治心力衰竭的作用机理。方法①以戊巴比妥致猫急性心力衰竭,从十二指肠灌人心复力悬液,给药后连续记录各项参数:心率(HR)、平均动脉压(MAP)、左室收缩压(LVSP)、左室舒张末压(LVEDP)、左室压力上升速度(+dp/dtmax)、左室压力下降速度(-dp/dtmax)、心输出量(CO)、心肌收缩力。用静脉注射西地兰0.2mg/kg作为阳性对照。②以异丙肾上腺素20mg/kg致大鼠心肌损伤,正常组与病理对照组口服生理盐水,给药组口服心复力冲剂或普奈洛尔,在光镜下观察心肌细胞的坏死程度及炎性细胞浸润情况。结果心复力冲剂对戊巴比妥致急性心力衰竭猫的心脏血流动力学无明显影响。而对异丙肾上腺素致大鼠心肌损伤、心肌缺血具有显著的防治作用,经心复力冲剂防治后,大鼠心肌损伤程度明显减轻,病灶范围减少,以修复反应为主。结论心复力冲剂对抗异丙肾上腺素所致大鼠的心肌损伤,对急性心力衰竭无防治作用。Objective To study the effect of Xinfuli Granula on cardiac failure in cats and rats.Methods The models of acute caediac fail- ure in cats were established by injecting pentobarbital.They were taken Xinfuli Granula by duodenum.HR、MAP、LVSP、LVEDP、+dp/dtmax and CO respectively isoprenaline 20mg/kg.The rats were divided randomly into following groups:the control group,the models group,the posi- tive control group,xinfuli groupl,xifuli group2.They were taken respectively relative “drugs” orally for 5 days.and injected subcutaneously iso- prenaline 20mg/kg for 4 days excrpt the control group.Pathological Changes of Myocardial Cells were determined.Results No affect of Xinfuli Granula on acute cardiac failur in cats.the level of Pathological Injury of Myocardial Cells in rats treated by xinfuli Granula were less than oth- ers.Conclusion xinfuli Granula has a good preventive and Protective effect on Myocardial Ceils in Rats with Myocaedial Injury and Ischemia and no effect on acute cardiac failure.

关 键 词：心复力冲剂 防治 心力衰竭 作用机理 血流动力学 

分 类 号：R259.416[医药卫生—中西医结合]