系统性红斑狼疮并发细菌感染的危险因素分析  

The Risk Factors of Bacterial Infection in Patients with Systemic Lupus Erythematosus

作　　者：李志军[1] 陈琳洁[1] 范晓云[1] 李茂胜[1] 

机构地区：[1]安徽省蚌埠医学院附属医院,233004

出　　处：《实用全科医学》2004年第5期383-384,共2页Applied Journal Of General Practice

摘　　要：目的　探讨SLE患者发生细菌感染的危险因素。方法　将 1 994年 1月～ 2 0 0 3年 1 2月收治的 1 90例并发细菌感染的SLE患者的相关危险因素与同期收治的 1 78例没有并发感染的SLE患者进行比较。先进行单因素 χ2 检验 ,然后对有显著差异的危险因素用非条件Logestic逐步回归法进行多因素分析。结果　肺部病变、血浆白蛋白 <30 g/L、应用大剂量糖皮质激素、超大剂量糖皮质激素冲击疗法、糖皮质激素联合应用细胞毒免疫抑制剂治疗、入院前应用广谱抗生素以及住院时间 >3周等 7项是SLE患者发生细菌感染的主要危险因素。结论　有上列危险因素存在的SLE患者应加强针对细菌感染的预防措施 ,并需密切监测有无感染发生。Objective To assess the risk factors of bacterial infection in patients with systemic lupus erythematosus (SLE). Methods A comparison was performed between 190 cases of SLE complicated with bacterial infection and 178 cases of SLE without infection. The differences between two groups were analyzed by chi-square test and stepwise regression. Results The seven major risk factors of SLE patients' infection were: lung disease, plasma albumin under 30g/L, application of large dose glucocorticoid, treatment of super-dose glucocorticoid, treatment of glucocorticoid associated with immunosuppressant, use of broad-spectrum antibiotics before hospitalization and the time in hospital over 3 weeks. Conclusions The patients with SLE related to the seven major risk factors should be monitored strictly to find out the infection and the preventive management should be strengthened to reduce the incidence of infection.

关 键 词：系统性红斑狼疮 细菌感染 危险因素 预防措施 

分 类 号：R593.241[医药卫生—内科学]