细胞周期素E在乳腺癌中的表达及意义  

Expression and Significance of Cyclin E in Breast Carcinoma

作　　者：赵亚娟[1] 杨磊[1] 智俐[1] 

机构地区：[1]内蒙古医学院第三附属医院病理科,内蒙古包头014010

出　　处：《包头医学院学报》2004年第2期116-117,共2页Journal of Baotou Medical College

摘　　要：目的 :本研究通过检测细胞周期素E(CyclinE)在乳腺癌中的表达及其与临床病理指标 (包括ER、PR受体 )的关系 ,探讨乳腺癌的生物学特性 ,分析其在乳腺癌的发生、转移中所起的作用。方法 :应用免疫组化S -P法检测 68例乳腺癌石蜡包埋标本及随机选取的同期癌旁组织 3 0例中CyclinE的表达情况。结果 :癌旁组织标本中CyclinE的阳性表达率 6.67%明显低于乳腺癌组织中CyclinE的阳性表达率 5 0 .0 0 %;CyclinE在乳腺癌Ⅱ～Ⅲ级中阳性表达率为 5 7.68%明显高于Ⅰ级中阳性表达率 2 5 .0 0 %;有淋巴结转移组CyclinE的阳性表达率 70 .0 0 %高于无淋巴结转移组的阳性率 3 4.2 1%%。结论 :CychinE可作为判断患者淋巴结转移及推断预后的指标之一。Objective:To investigate the biological features of breast carcinoma and analyze Cyclin E’s functions in occurrence and metastasis of breast carcinoma by the examination of Cyclin E,and their relationship with clinical-pathological features index including ER,PR. Methods: A total of 68 paraffin-embedded tissue of breast carcinomas and 30 non-carcinomatous breast tissues were observed by the use of S-P method to examine the expression of proteins. Results: The positive rate of Cyclin E in 30 non-carcinomatous breast tissues were 6.67%. The positive rate of Cyclin E in 68 breast carcinomas were 50.00%.The difference between the two groups of patients was significant.And the expression level of them was significantly higher in the tumors than that in the non-carcinnomatous breast tissues. The positive expression rate of Cyclin E was 25.00%and 57.68% in classⅠand class Ⅱ~Ⅲ of breast carcinoma respectively, having significant difference . Breast tumor malignant degree increased when Cyclin E positive expression increased. The positive rate in the group with lymph nodes metastasis was 70.00%, which was higher than that of non-lymph nodes metastasis.The difference was significant. Conclusion: The findings suggest that the expression of Cyclin E might be a useful marker for predicting the lymph node metastasis, and the prognosis of breast carcinoma.

关 键 词：细胞周期素E 乳腺癌 基因表达 肿瘤 CYCLINE 

分 类 号：R737.9[医药卫生—肿瘤]