^(125)I-眼镜蛇神经毒素透鼻黏膜吸收及冰片的促进作用研究  

Study on permeation profile of 125I-α-cobratoxin across nasal mucosa and the enhancement of borneol

作　　者：刘志贤[1] 李范珠[2] 陈建明[3] 方剑文[2] 

机构地区：[1]沈阳市骨科医院药剂科,辽宁沈阳110044 [2]浙江中医学院药学系,浙江杭州310053 [3]第二军医大学药学院,上海200433

出　　处：《药学实践杂志》2004年第4期200-202,共3页Journal of Pharmaceutical Practice

摘　　要：目的:考察125I-(a-cobratoxin,Nt)透鼻黏膜吸收的情况及冰片的促进作用。方法:以大鼠、家兔、狗和羊为研究对象,以放射性活性(每分钟计数,count per minute,cpm)为指标,采用离体渗透鼻黏膜实验、在体渗透鼻黏膜重循环实验等方法,研究125I-Nt对不同动物透鼻黏膜吸收的情况及冰片的促进作用。结果:研究发现,Nt很难透过鼻黏膜吸收,但在冰片作用下吸收显著增加。结论:冰片对Nt透鼻黏膜吸收有显著促进作用。Objective: To determine the permeation profile of 125I-α-cobratoxin across different animals'nasal mucosa and the enhancement of borneol. Methods:The rabbits、dogs and goats was selected as model animals, radioactivity (count per minute, cpm)as index, and a method called permeation of nasal mucosa in vitro was adopted,together with repeated cycle technique in situ to compare the permeation profile of Nt across different animals'nasal mucosa in vitro in order to confirm the permeation of these animals and the effect of borneol. Results: Nt could penetrate the nasal mucosa of different animals and be absorbed, but the amount was low. However, the absorption could be enhanced under the help of borneol. Conclusion:Borneol could enhance the absorption of Nt arcoss the nasal mucosa.

关 键 词：眼镜蛇神经毒素 透黏膜吸收 冰片 放射性活性 

分 类 号：R996.3[医药卫生—毒理学]