联合用药治疗糖尿病肾病的疗效观察  

Combination treatment of diabetic nephropathy

作　　者：宁鲁蓉[1] 孙少俐[1] 戚加永[1] 

机构地区：[1]山东烟台毓璜顶医院干部病房,264000

出　　处：《中国临床保健杂志》2004年第4期262-263,共2页Chinese Journal of Clinical Healthcare

摘　　要：目的　寻找及探讨对糖尿病肾病 (DN)有效的干预治疗方法。方法　选择已确诊的糖尿病肾病白蛋白尿 (MA) >30mg/L、血肌酐 (Scr)水平 <2 6 5 μmol/L(≤ 3mg/dl)的病例 16例 ,分为正常肾功能组及异常肾功能组 ,两组分别给予低蛋白饮食、胰岛素、抗血小板集聚、血管紧张素转换酶抑制剂 (ACEI)、抗凝等药物联合治疗 ,3周后复查MA、Scr、2 4h尿蛋白定量 (TP)、血尿素氮 (BUN) ,观察空腹血糖 (FBG)及平均动脉压(MAP)。结果　治疗后正常肾功能组MA、TP明显下降 (P <0 0 1) ,FBG、MAP下降 (P <0 0 5 ) ;异常肾功能组MA、TP、BUN、Scr、FBG下降 (P <0 0 5 ) ,但MA、TP下降幅度小于肾功能正常组 ,MAP无明显变化。结论　联合治疗能够较明显降低DN患者的MA及TP的水平 。Objective To search for an effective intervement therapeutic method for diabetic nephropathy(DN).Methods Sixteen DN patients with albuminuria >30mg/L,Scr<265μmol/L were investigated.The patients were divided into A group(with normal renal function) and B group(with abnormal renal function).The two-group patients were given low protein diet,insulin,anti-platelet aggregation agents,ACEI,anticoagulant,urinary acbumin excretion(UAE),Scr,TP,BUN,FBG and MAP of the patients were re-exmained after 3-week treatment.Results After treatment,UAE,TP of A group patients reduced significantly(P<0.01),FBG,MAP lowered(P<0.05),UAE,TP,BUN,Scr,FBG of B group patients reduced(P<0.05),but there was no significant change in MAP after treatment.Conclusion Combination treatment can lower UAE and TP of DN patients,and improve renal function of patients with abnormal renal function,so DN should be treatment early.

关 键 词：糖尿病肾病 联合治疗 疗效 

分 类 号：R587.2[医药卫生—内分泌]