重症阿片类中毒及其纳洛酮抢救的疗效观察  

The clinical features of serious opioid overdoses and effects of naloxone

作　　者：陈雪梅[1] 徐昉[1] 文扬 

机构地区：[1]重庆医科大学临床学院急诊科,重庆400016 [2]重庆建设医院急诊科,重庆400050

出　　处：《重庆医科大学学报》2004年第4期518-520,共3页Journal of Chongqing Medical University

摘　　要：目的 :探讨重症阿片类中毒的临床特点及其纳洛酮的疗效。方法 :观察 32例急诊收治的重症阿片类中毒患者的临床特征 ,以及纳洛酮治疗后患者的意识和呼吸的改变、起效时间及治愈率。结果 :重症阿片类中毒患者临床上表现为意识障碍、呼吸抑制、瞳孔缩小、血压下降 ,严重的可出现呼吸、心跳骤停。经纳洛酮抢救后 ,患者呼吸恢复、神志转清 ,血压恢复正常 ,而且起效迅速 ,治愈率可达 90 .6 %。结论 :重症阿片类中毒患者病情危重 ,纳洛酮治疗起效迅速、疗效肯定 。Objective:To study the clinical features of serious opioid overdoses and effects of naloxone.Methods:32 cases of serious opioid overdose were involved.All patients were treated with naloxone,the change in consciousness and respiration,cure rate and the interval time,during which naloxone takes effect were observed.Results:Abnormal mental status,substantially decreased respiration,miotic pupils,and hypotension,even the apnea and cardiac arrest were found to be clinical characteristics.Naloxone could quickly reverse the respiratory depression,abnormal mental status,and hypotension.The cure rate was 90.6%.Conclusion:Effects of naloxone on serious opioid overdoses is confirmed,which is worthy of being widely used in clinic.

关 键 词：阿片类中毒 纳洛酮 治疗 

分 类 号：R595.4[医药卫生—内科学]