瘢痕水泡液中肿瘤坏死因子、白细胞介素6的变化对瘢痕形成的作用  

Effects of changes in tumor necrosis factors and interleukin-6 in scar blisters on scar formation

作　　者：谢有富 吕海峰 陈怡霓 梁达荣 

机构地区：[1]暨南大学附属广州市红十字会医院烧伤整形科,广东省广州市510220

出　　处：《中国临床康复》2004年第23期4760-4761,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的研究瘢痕早期的水泡液中肿瘤坏死因子(TNF)、白细胞介素6(IL-6)的变化以探索研究瘢痕的新方法和瘢痕形成的可能机制。方法采用深度烧伤患者愈后增生性瘢痕的水泡液,以化学发光酶免疫法测定患者血和瘢痕水泡液中TNF,IL-6的含量,监测瘢痕早期组织中TNF,IL-6的变化。结果深度烧伤患者愈后血液中的TNF,IL-6的含量无升高;增生性瘢痕水泡液中TNF,IL-6含量显著增加(P<0.01),其高水平持续至少3个月(P>0.05)。结论瘢痕水泡液可作为研究瘢痕发生发展的重要手段;瘢痕形成早期组织中TNF,IL-6含量增高是瘢痕增生的重要因素。AIM:To investigate the changes of tumor necrosis factors(TNF)and interliukin 6(IL 6) in blisters at the earlier period of scar, and to explore the new method of treating scar and the probable mechanism of the formation of scar.METHODS:The blisters of hyperplastic scars were obtained from the patients with deep burn after recovery. The contents of TNF and IL 6 in blood and blisters were tested with chemiluminoimmunoassay.The changes of TNF and IL 6 in scar tissues at the early stage were monitored.RESULTS:The contents of TNF and IL 6 were not increased in blood of the patients with deep burn, but significantly increased in scar blisters(P< 0.01),and the increased levels lasted for at least three months.CONCLUSION:The scar blisters can be used as an important method for the studies on the occurrence and development of scar.The increase of TNF and IL 6 contents in tissue at the earlier period of cicatrisation is the important factor of scar hyperplasia.

关 键 词：瘢痕 肿瘤坏死因子 白细胞介素6 

分 类 号：R6196[医药卫生—外科学]