藻酸双酯钠对下肢动脉硬化闭塞症疗效观察  

TREATMENT OF ATHEROSCLEROSIS OBLITERANS BY POLYSACCHARIDE SULFATE

作　　者：孙成林[1] 单丽沈[2] 张京红[1] 段志泉[1] 辛世杰[1] 张强[1] 

机构地区：[1]中国医科大学附属第一医院血管外科 [2]中国医科大学附属第二医院儿科

出　　处：《中国心血管病研究》2004年第9期689-690,共2页Chinese Journal of Cardiovascular Research

摘　　要：目的　观察藻酸双酯钠 (PSS)对下肢动脉硬化闭塞症患者的临床疗效。方法　下肢动脉硬化闭塞症患者 35例应用PSS 10 0～ 2 0 0mg/d ,缓慢静滴 ,连用 10～ 14d。治疗前后分别观察临床症状、踝 /肱指数、下肢动脉狭窄程度(直径 )及血流峰速和血糖、血脂及凝血三项等实验室检查。结果　治疗后的患者临床症状明显好转 ,总有效率达91.4 % ,无出血及其他不良反应。治疗后与治疗前相比血脂明显下降 ,差异有统计学意义 (P <0 .0 5 ) ,血糖有所下降 ,但差异无统计学意义 ;凝血三项数据显示有所升高 ,但差异无统计学意义 ;动脉狭窄程度及血流峰速、踝 /肱指数值差异均无统计学意义。结论　PSS可扩张外周血管 ,降低血管阻力 ,增加肢体血流量 ;可明显降低血脂、降低血液粘度 ;改善微循环、促进侧支循环的形成 ,是一种较好的微循环障碍改善剂 。Objective To investigate the efficacy of polysaccharide sulfate(PSS) on the treatment of Atherosclerosis Obliterans (ASO). Methods 35 cases were given PSS 100～200mg/d for 10～14 days.Symptoms were observed,and some laboratory examination,AAI and ultrasonic examination were measured before and after the treatment. Results Most cases show obvious improvement of peripheral circulation.Serum total cholesteral(TC) and Serum triglyceride(TG) were decreased significantly(P<0.05),other laboratory examination as blood sugar and so on have no significant difference. Conclusion PSS have the efficacy on the treatment of ASO by improving circulatory disorder.

关 键 词：藻酸双酯钠 下肢动脉硬化闭塞症 

分 类 号：R543.5[医药卫生—心血管疾病]