脉冲电流电磁场对淋巴细胞染色单体互换的影响  

Experimental Investigation of Pulsed Current Electromagnetic Fields on Chromatid Exchange of Lymphocytes

作　　者：姚学玲[1] 陈景亮[1] 徐晓宙[2] 徐传骧[1] 

机构地区：[1]西安交通大学电气工程学院,西安710049 [2]西安交通大学生命科学与技术学院,西安710049

出　　处：《西安交通大学学报》2004年第8期855-859,共5页Journal of Xi'an Jiaotong University

摘　　要：通过不同模式的脉冲电流电磁场(PCEMFs)对离体的人体外周血淋巴细胞进行电磁辐射,初步得出PCEMFs对淋巴细胞姊妹染色单体互换(SCE)影响的规律:细胞SCE和破坏的程度与PCEMFs的磁感应强度Bm及其变化梯度dB/dt呈正相关关系.提出了使细胞SCE发生变异的临界参考指标,其中Bm为0 15T,dB/dt为1 8×104T/s,破坏的临界参考指标分别为2 64T和3 3×104T/s,为强电流脉冲放电环境的电磁防护研究提供了实验依据.细胞SCE及破坏的程度和PCEMFs中电场和磁场的空间相对位置有关,电场和磁场相互垂直的PCEMFs对细胞的影响程度比其他结构形式的PCEMFs显著.The human peripheral lymphocytes are placed in different models of radiated pulsed current electromagnetic fields (PCEMFs) environments, and the elementary experimental results illustrate that sister chromatid exchange (SCE) and breaking of the human lymphocytes are mainly related to the magnetic induction amplitude Bm and its rising gradient dB/dt of PCEMFs. The critical reference values of SCE are put forward, where the critical reference values of aberrance refer to 0.15 T(Bm) and 1.8×104 T/s(dB/dt), the values of damage approach to 2.64 T(Bm) and 3.3×104 T/s(dB/dt) respectively. These data can provide a criterion to study electromagnetic protection in high pulsed-current discharging environment. SCE and damage of the human lymphocytes are obviously dependent upon the space structure of pulsed electric and magnetic fields, and the PCEMFs where the electric field is orthogonal to the magnetic fields have more notable influence than the other.

关 键 词：脉冲电流电磁场 姊妹染色单体互换 临界参考指标 

分 类 号：Q64[生物学—生物物理学]