佐匹克隆对大鼠化学点燃效应的影响  

EFFCTS OF ZOPICLONE ON THE PENTYLENETETRAZOLE KINDLING IN RATS AND SEMICARBAZIDE-INDUCED CONVULSION IN MICE

作　　者：臧东莲[1] 胡斌 胡美霞 张芳[1] 王蕾[1] 

机构地区：[1]青岛大学医学院药理学教研室,山东青岛266021 [2]聊城市东昌府区卫生防疫站 [3]莘县卫生防疫站

出　　处：《青岛大学医学院学报》2004年第2期137-138,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的　探讨佐匹克隆 (zpl)对大鼠戊四唑 (PTZ)化学点燃和对小鼠氨基脲惊厥的影响。 ②方法制备大鼠PTZ化学点燃模型 ,对已点燃大鼠分别给予zpl 1 .5、3.0、5 .0mg/kg灌胃 ,30min后PTZ 35mg/kg腹腔注射 ,观察大鼠行为发作情况 ,大鼠行为发作按Ono标准分级 ,计算 6级发作百分率并与用药前比较 ;小鼠zpl(0 .5、1 .5、3.0mg/kg)灌胃给药 30min后 ,氨基脲 (1 5 0mg/kg)尾静脉注射 ,观察小鼠行为活动变化 ,记录小鼠阵挛惊厥的潜伏期及存活时间。③结果　zpl 3.0、5 .0mg/kg可降低点燃大鼠行为发作强度 ,与用药前比较其Ono分级和 6级发作的百分率均有显著性差异 (t =2 .1 9,P <0 .0 5 ,t =5 .2 6 ,P <0 .0 1 ;χ2 =4 .6 8,P <0 .0 5 ,χ2 =1 0 .74 ,P <0 .0 1 ) ;zpl 1 .5、3.0mg/kg灌胃用药延长了小鼠氨基脲惊厥的潜伏期及存活时间 ,与对照组比较有显著性差异 (t =2 .2 0～ 3.81 ,P <0 .0 5、0 .0 1 )。Objective To study the effect of zopiclone on pentylenetetrazole(PTZ)-kindling in rats and semicarbazide-induced convulsion in mice. Methods A PTZ-kindling model was established in rats. The kindled rats were given zopiclone(zpl) 1.5 , 3.0, 5.0 mg/kg intragastrically, respectively, and PTZ 35 mg/kg intraperitoneally 30 min later. The seizure severity was observed with Onos method and compared with those of the non-zpl treatment. The mice were given zpl 0.5, 1.5, 3.0 mg/kg intragastrically, respectively, and 30min later semicarbazide 150 mg/kg intravenously. The latency of convulsion and span of survival were recorded and compared with those of the control group. Results zpl 3.0, 5.0 mg/kg inhibited the seizure of kindled rats significantly, and the severity of seizure were inhibited markedly compared with the non-zpl treatment ( t=2.19, P<0.05, t= 5.26 , P<0.01; χ 2=4.68, P<0.05, χ 2=10.74, P <0.01); zpl 1.5, 3.0 mg/kg obviously prolonged the latency of seizure and the span of survival in semicarbazide-induced seizure in mice compared with the control group ( t=2.20-3.81, P <0.05,0.01). Conclusion zpl may play an inhibitory role in PTZ-kindled rats and semicarbazide-induced convulsion in mice.

关 键 词：佐匹克隆 点燃效应 戊四唑 大鼠 WISTAR 

分 类 号：R969.4[医药卫生—药理学]