角燕胶囊对小鼠免疫功能的影响  

Effects of Mobula capsules on immune function in mice

作　　者：沈先荣 [1] 蒋定文 [1] 贾福星 [1] 储智勇  陈美华  周菊珍 [1] 

机构地区：[1]海军医学研究所海洋生物研究中心,上海,200433 [2]上海澳博海洋生物技术开发有限公司,上海,200433

出　　处：《中国海洋药物》2004年第4期31-34,共4页Chinese Journal of Marine Drugs

基　　金：上海澳博海洋生物技术开发有限公司资助。

摘　　要：目的 观察深海鱼类提取物角燕胶囊对小鼠免疫功能的影响。方法从海洋大型软骨鱼角燕的有效部位中制备得到角燕胶囊,用0.043,0.087,0.26g·kg-1剂量的角燕胶囊给小鼠灌胃30d,观察其对小鼠免疫功能的调节作用。结果 在0.087g·kg-1和0.26g·kg-1剂量,角燕胶囊能显著提高小鼠的血清溶血素含量、增加脾细胞的溶血空斑数、明显增强小鼠的碳廓清能力、促进小鼠的迟发型超敏反应、促进ConA诱导的小鼠脾淋巴细胞转化能力、提高NK细胞的杀伤活性及腹腔巨噬细胞的吞噬能力。结论 角燕胶囊能明显调节机体的细胞免疫与体液免疫功能,促进NK细胞的杀伤活性及巨噬细胞的吞噬能力。Aim To study the effects of Mobula capsules on immune function in mice. Methods Mobula capsules were prepared from sea fish-Mobula. Its effects on immune system in mice were studied by the detections of T lymphocyte proliferation,the activities of NK cells and macrophage, the clearance of charcoal particle, DTH, PFC, and the serum hemolysins level after 30 d nutrition of Mobula capsules at doses of 0. 043,0. 087,0. 26g·kg-1. ResultsThe proliferation of spleen T lymphocytes, the activity of NK cells, the phagocytic activity of peritoneal macrophage , the clearance of charcoal particle, the delayed type hypersensitivity (DTH) , the plague-forming cell(PFC) and the serum hemolysins in mice were significantly increased at doses of 0. 087g·kg-1 and 0. 260g·kg-1 (P<0.05), respectively. ConclusionThe results showed that Mobula capsules have an obvious effect on improving immune function.

关 键 词：海洋生物 角燕 免疫调节 NK细胞 PFC 迟发型超敏反应 

分 类 号：Q959.266[生物学—动物学] R967[医药卫生—药理学]